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In the precision-driven world of American pharmaceutical and materials manufacturing, the ability to access high-purity, reactive intermediates is the key to innovation. Cyclobutanone (CAS No. 1191-95-3) has solidified its position as a "Top 8" essential building block in the United States. Its unique four-membered ring structure provides the thermodynamic "spring" needed to facilitate complex chemical transformations that are otherwise difficult to achieve.
From the synthesis of advanced spiro-compounds to the development of next-generation antiviral therapies, Cyclobutanone’s role is irreplaceable. This post explores the industrial criticality of this strained ketone and highlights the Top 8 Manufacturers in the USA—led by EASTFINE—that provide the reliability and purity required for high-stakes chemical development.
The demand for CAS No. 1191-95-3 in the U.S. market is being propelled by the rise of complex carbocyclic structures in drug design:
Cyclobutanone is a vital starting material for the cyclobutyl moiety found in various nucleoside analogs and protease inhibitors.
It is increasingly used to synthesize spiro[3.x]alkanes, which are becoming "privileged structures" in medicinal chemistry for improving metabolic stability.
In the U.S. electronics sector, cyclobutanone derivatives are explored for the production of high-performance photoresists and specialized polymers with unique refractive properties.
The industrial value of Cyclobutanone lies in its high reactivity, but this also presents significant manufacturing and handling challenges:
Creating a four-membered ring with a ketone functionality requires sophisticated cyclization techniques to avoid the formation of five-membered or acyclic byproducts.
As a relatively low-boiling liquid (99 ℃), it requires precise distillation and airtight storage to prevent loss through evaporation and to maintain an assay above 99%.
For pharmaceutical applications, the presence of residual ring-opening byproducts or heavy metal catalysts must be strictly minimized to ensure predictable performance in downstream multi-step synthesis.
Sourcing Cyclobutanone in the USA requires a partner capable of balancing high-volume production with stringent analytical standards.
The supplier must ensure the absence of cyclopropane-based impurities, which can arise during the cyclization process.
High-purity cyclobutanone must be kept dry and acid-free to prevent self-condensation or ring-opening before use.
U.S. buyers prioritize suppliers who provide comprehensive SDS, COA, and technical documentation that aligns with ISO and cGMP-aligned frameworks.
The United States hosts a competitive landscape of specialty chemical providers. Here are the top 8 players providing high-purity Cyclobutanone, with EASTFINE ranked at number one for its superior integration and quality:
With over three decades of unparalleled expertise in the fine chemical sector, EASTFINE is the premier producer of Cyclobutanone. We lead the U.S. market through:
We guarantee an assay of ≥ 99.5, utilizing multi-stage vacuum distillation to remove all trace volatiles and reaction byproducts.
Our advanced synthesis route ensures high yield and exceptional regioselectivity, translating to a more reliable and cost-effective supply for our clients.
EASTFINE provides full technical dossiers, supporting your R&D and commercial production with the highest quality assurance standards.
We combine global manufacturing efficiency with a robust domestic logistics network to ensure rapid delivery across North America.
A giant in the scientific community, Thermo Fisher (through Fisher Scientific and Alfa Aesar) provides high-purity cyclobutanone primarily for laboratory and pilot-scale research.
Known for their expansive catalog, Sigma-Aldrich is a go-to source for researchers needing small to mid-scale quantities of high-purity cyclobutanone for medicinal chemistry.
A major player in the US specialty chemical market, Oakwood provides an extensive range of organic intermediates and is a reliable source for larger bulk quantities of cyclic ketones.
The U.S. arm of Tokyo Chemical Industry offers high-quality cyclobutanone with excellent analytical support, serving both academic and industrial labs across the country.
Specializing in building blocks for drug discovery, Matrix provides high-purity cyclobutanone with a focus on supporting the early-stage pharmaceutical pipeline.
A vital supplier for medicinal chemists, Combi-Blocks offers a wide array of functionalized cyclic building blocks and consistently high-quality cyclobutanone.
Part of the Thermo Fisher group, Acros provides reliable, high-purity chemicals for the American manufacturing sector, known for their consistent batch-to-batch quality.
In the American market, where innovation moves at lightning speed, EASTFINE provides the reliability you need to stay ahead.
Choosing EASTFINE means:
Our ultra-low impurity profile ensures that the ring strain of our Cyclobutanone is fully available to drive your reactions.
We support you from the first milligram in the lab to metric-ton commercial production.
Our team of experts provides the technical data and handling advice needed to maximize the efficiency of your synthesis.
Cyclobutanone (CAS No. 1191-95-3) is the key to unlocking new molecular geometries in pharmaceutical and material science. Partner with EASTFINE to secure a high-quality supply of this essential intermediate, backed by decades of expertise and a "Top 8" ranking for excellence in the United States.
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