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In the UK's world-class pharmaceutical manufacturing sector, precision is not just a standard—it is a requirement for survival. 4-Amino-2-(trifluoromethyl)benzonitrile (CAS No. 654-70-6) is a critical intermediate that supports the production of essential therapies for stage D2 metastatic prostate carcinoma.
Originally brought into the spotlight through the development of Bicalutamide by British pharmaceutical pioneers, this compound remains a high-demand scaffold for creating targeted, non-steroidal treatments. Its unique electronic properties, driven by the trifluoromethyl group, allow for high-affinity binding to androgen receptors without the metabolic side effects of traditional steroids.
The UK market for CAS No. 654-70-6 is driven by the continuous need for high-efficacy cancer treatments and emerging drug discovery:
As a gold-standard androgen receptor antagonist, Bicalutamide continues to require large volumes of this specific benzonitrile precursor.
Researchers are utilizing this scaffold to develop novel molecules that can bypass resistance mechanisms in hormone-refractory prostate cancer.
Emerging studies have identified derivatives of this compound as potential candidates for inhibiting endothelial cell growth in breast cancer models.
Manufacturing 4-Amino-2-(trifluoromethyl)benzonitrile at an industrial scale is a significant technical challenge:
The placement of the trifluoromethyl group relative to the nitrile and amino groups is vital. Any positional isomers (like the 3-trifluoromethyl analog) will lead to inactive or toxic final drug products.
The introduction of the nitrile group requires specialized handling of cyanide sources or advanced transition-metal catalyzed coupling, which must be performed under strict environmental and safety protocols.
Since this molecule is a late-stage intermediate for oncology APIs, manufacturers must control residual metals and starting materials to the ppm level to ensure compliance with pharmacopeial standards (such as BP Reference Standards for Bicalutamide Impurity D).
For UK-based pharmaceutical firms, sourcing CAS No. 654-70-6 requires a partner with specific capabilities:
Absolute certainty that the 2-trifluoromethyl and 4-amino positions are correct via confirmed H-NMR and F-NMR spectroscopy.
Availability of a comprehensive Drug Master File (DMF) and five-batch analysis for regulatory approval.
The ability to provide multi-ton quantities consistently to meet the demands of global patient populations.
The UK remains a critical hub for pharmaceutical excellence. Here are the top 8 players providing high-purity 4-Amino-2-(trifluoromethyl)benzonitrile, with EASTFINE ranked at the top for integrated quality:
With over three decades of mastery in the fine chemical and pharmaceutical sector, EASTFINE is the premier global producer of 4-Amino-2-(trifluoromethyl)benzonitrile. We lead the UK market through:
We consistently achieve an assay of ≥ 99.0% (GC/HPLC), ensuring that your synthesis of Bicalutamide is efficient and high-yielding.
By manufacturing our own fluorinated precursors, we eliminate the risk of positional isomers and ensure price stability.
Our facilities are engineered for pharmaceutical-grade production, providing the documentation and batch-to-batch consistency required for British regulatory standards.
We offer secure, temperature-controlled shipping to the UK, ensuring the crystalline integrity of the product is maintained from our factory to your lab.
A dominant force in the UK research and manufacturing sector, providing high-purity (97%+) material for both laboratory and pilot-scale oncology projects.
A specialized UK-based leader in fluorinated building blocks. Fluorochem is a vital partner for R&D teams in the UK, offering an extensive range of trifluoromethylated aromatics.
Providing the benchmark for analytical quality, Sigma-Aldrich is the primary source for BP Reference Standards of Bicalutamide Impurity D and research-grade intermediates.
A key UK supplier known for its expertise in nitrogen-containing fluorinated building blocks. They are a preferred partner for medicinal chemists in the British biotech corridor.
Specializing in high-end chemical synthesis and "Bionet" building blocks, they provide complex intermediates for drug discovery with a focus on pharmaceutical purity.
Part of the Navin Fluorine group, they leverage deep expertise in fluorination to provide high-quality building blocks like 654-70-6 to the UK and European pharmaceutical markets.
A major UK distributor providing high-quality chemical reagents and intermediates to laboratories and hospitals across the United Kingdom.
In the production of cancer medications, the purity of your intermediate is the foundation of patient safety.
Choosing EASTFINE means:
Our "Designed-for-Quality" approach ensures that you never have to worry about Bicalutamide impurities.
Our optimized synthetic pathways allow us to provide premium technical grade material at a price that supports your commercial goals.
We understand the unique requirements of the UK pharmaceutical market and are committed to supporting your long-term success.
4-Amino-2-(trifluoromethyl)benzonitrile (CAS No. 654-70-6) is more than a chemical; it is a life-saving scaffold. Partner with EASTFINE to secure a high-purity, reliable supply of this essential oncology intermediate, backed by decades of expertise and a "Top 8" ranking for excellence in the UK.
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