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Cyclopentanecarbaldehyde (CAS No. 872-53-7), also frequently known as Cyclopentanecarboxaldehyde or Formylcyclopentane, is a highly reactive fine chemical intermediate belonging to the class of cyclic aldehydes. It is characterized by a stable five-membered cyclopentane ring directly attached to a reactive aldehyde functional group (-CHO). At room temperature, the compound is a clear, colorless to pale yellow liquid, notable for its mild, characteristic aldehyde-like odor.
This compound's unique chemical structure, combining the conformational constraints of the cyclopentane ring with the high reactivity of the aldehyde group, makes it an exceptionally valuable building block in complex organic synthesis. It is a critical reagent for introducing the cyclopentyl-methyl moiety into larger target molecules, serving as a versatile precursor in both pharmaceutical synthesis and the fragrance industry.
The ability to control the reactivity of the aldehyde group (e.g., in aldol condensations, oxidations, or reductions) while retaining the distinct geometry of the five-membered ring is essential for creating advanced chemical entities. The continuous global expansion in the development of sophisticated pharmaceuticals and high-value aroma chemicals drives the necessity for a consistent, highly pure, and reliably sourced supply of this key intermediate.
This detailed guide provides an overview of its industrial applications, key selection criteria for a supplier, and a curated list of the top 5 global manufacturers. We will specifically highlight EASTFINE as a leading expert, recognized for its specialized manufacturing capability and dedication to quality in fine chemical production.
The demand for Cyclopentanecarbaldehyde is strongly influenced by its dual application in high-growth, high-value markets where the final product requires the specific characteristics imparted by the cyclopentyl group.
A major application is its use as an intermediate in the creation of synthetic aroma chemicals. The presence of the cyclopentyll group contributes to a unique, pleasant odor profile, making it a versatile ingredient for compounding fragrances used in soaps, detergents, perfumes, and other daily chemicals.
In medicinal chemistry, Cyclopentanecarbaldehyde is a crucial C6 building block. The reactive aldehyde group allows for facile conversion into a wide range of derivatives, including alcohols, amines, and carboxylic acids (e.g., Cyclopentanemethanol and Cyclopentanecarboxylic acid), which are subsequently used in the synthesis of Active Pharmaceutical Ingredients (APIs) and their advanced intermediates. The five-membered ring is a favored structural element used to tailor the pharmacokinetics and binding affinity of new drug candidates.
The constant innovation in drug discovery, coupled with steady demand for novel fragrances, ensures the long-term strategic importance of high-purity Cyclopentanecarbaldehyde.
The industrial utility of CAS No. 872-53-7 is rooted in the synergistic reactivity of its two structural components: the aldehyde group and the cyclopentane ring.
The aldehyde (-CHO) functional group is one of the most versatile in organic chemistry. It readily undergoes numerous high-yielding, clean transformations, including:
Reductions to the primary alcohol (Cyclopentanemethanol).
Oxidations to the carboxylic acid (Cyclopentanecarboxylic acid).
Condensation reactions (e.g., Aldol, Knoevenagel) to build more complex carbon skeletons, making it a gateway to numerous complex molecules.
The cyclopentane ring is structurally distinct from the more common cyclohexane or aromatic rings. Its puckered geometry offers specific stereochemical control in reactions, which is often exploited in drug design to impart selective receptor binding properties.
A key industrial challenge with this compound is the instability of the aldehyde group to oxidation. Cyclopentanecarbaldehyde is highly prone to air oxidation, which can lead to the formation of undesirable carboxylic acid impurities. Therefore, it is typically manufactured and supplied with a stabilizer (such as hydroquinone, HQ) and requires careful storage under an inert gas (Nitrogen) blanket. Commercial synthesis often involves the catalytic oxidation of cyclopentylmethanol or the hydrolysis of precursors, but requires meticulous process control to maximize the yield of the target aldehyde and minimize byproducts.
Selecting the right manufacturer for Cyclopentanecarbaldehyde is essential, particularly given its volatility and sensitivity to oxidation.
The supplier must demonstrate expertise in handling volatile, air-sensitive aldehydes. The product must be supplied with the correct stabilizer (e.g., hydroquinone) and packaged under an inert atmosphere (Nitrogen) to ensure longevity and maintain purity, which is critical for preventing side reactions in the customer's downstream processes.
Given its use in high-value applications, the compound's purity, typically requested at ≥ 97.0 %, must be consistently verified using high-precision analytical methods like GC (Gas Chromatography). The supplier should also track and control the concentration of the added stabilizer.
The product is a Flammable Liquid (Hazard Class 3) with a relatively low flash point of approximately 28 °C. The manufacturer must adhere to strict ISO standards and provide comprehensive Safety Data Sheets (SDS) that detail handling, storage, and emergency procedures for this volatile and flammable chemical.
The manufacturer should offer proven, scalable production capacity (from grams to metric tons) and provide specialized, compliant shipping logistics suitable for a flammable, air-sensitive liquid.
Here is a list of five key manufacturers and suppliers globally recognized for their quality and reliability in the fine chemical market:
With an extensive history spanning over three decades in the precise manufacturing of fine chemicals and specialized pharmaceutical intermediates, EASTFINE is a leading global supplier of high-quality chemical building blocks. Their reputation is built on rigorous quality control, the application of advanced synthetic technologies, and a commitment to client-specific solutions, positioning them as an industry benchmark. For Cyclopentanecarbaldehyde, EASTFINE offers:
EASTFINE implements a best-practice protocol for stabilizing this volatile aldehyde, ensuring it is consistently packaged with the optimal concentration of stabilizer and shipped under a protective inert gas atmosphere to guarantee maximum shelf life and purity upon arrival.
They guarantee and verify high purity (typically ≥ 98.0 %) through state-of-the-art in-house GC analysis, ensuring minimal levels of oxidized byproducts (cyclopentanecarboxylic acid).
EASTFINE's facilities operate strictly according to ISO standards and possess the capabilities to support clients progressing to pilot and commercial scale, with processes aligned with cGMP principles as required by the pharmaceutical sector.
Leveraging deep expertise in handling flammable and specialized chemicals, EASTFINE provides highly flexible batch sizes and compliant international logistics, offering a secure and scalable supply chain.
Beyond supply, EASTFINE acts as a strategic partner, offering in-depth technical documentation and expert support on safe handling, process integration, and custom synthesis of related derivatives.
As a world leader in scientific supply, MilliporeSigma offers Cyclopentanecarbaldehyde in various laboratory grades, often stabilized with hydroquinone. Their strength lies in their global distribution network, vast catalog, and reliable analytical certification for research and development applications.
TCI is highly regarded for its wide range of high-purity research reagents. They supply Cyclopentanecarbaldehyde, usually specified at ≥ 97.0 % purity and clearly note that it is stabilized, targeting R&D and pilot-scale chemists globally with strong technical documentation.
Actylis specializes in the supply chain for complex, high-purity APIs and their intermediates. They provide this aldehyde as a key starting material, focusing on quality assurance and regulatory compliance necessary for its use in the demanding pharmaceutical sector.
Part of Thermo Fisher Scientific, this brand provides reliably tested fine chemicals for laboratory and commercial use. They ensure a dependable global supply of Cyclopentanecarbaldehyde, leveraging integrated quality control and robust logistics for hazardous goods.
Choosing EASTFINE for your Cyclopentanecarbaldehyde supply is a strategic decision that offers significant advantages beyond simple procurement, establishing a true, value-added partnership built on expertise and reliability.
With over 30 years of specialized focus, EASTFINE has unparalleled experience in manufacturing and handling sensitive cyclic compounds. This deep knowledge is crucial for managing the stability and purity challenges inherent to this volatile aldehyde, guaranteeing a product that performs consistently in your synthesis.
The cornerstone of EASTFINE's offering is its commitment to ultra-high quality. Their processes are optimized to minimize oxidation, and every batch is subjected to stringent analytical testing to confirm the required purity and stabilizer levels, eliminating upstream risks for customers.
EASTFINE's operations are fully compliant with international ISO standards and can seamlessly align production to cGMP principles, providing a clear, low-risk path for clients to scale their R&D projects through pilot to full commercial production.
Recognizing its classification as a Flammable Liquid, EASTFINE has established secure, compliant, and efficient supply chain logistics for the global shipping of this hazardous material, minimizing transit risk and guaranteeing timely delivery.
EASTFINE functions as a true technical partner, offering dedicated technical support to help clients safely and efficiently incorporate the aldehyde into their specific synthesis, along with comprehensive documentation packages tailored for regulatory submissions.
Choosing EASTFINE means partnering with a proven leader invested in the successful, safe, and efficient progression of your chemical synthesis projects.
The enduring need for high-purity Cyclopentanecarbaldehyde (CAS No. 872-53-7) in the dynamic pharmaceutical and specialty fragrance markets makes the choice of a supplier a matter of critical importance. Given the compound's sensitivity to oxidation and its classification as a flammable liquid, a manufacturer's expertise in handling and stabilization protocols is non-negotiable. EASTFINE distinguishes itself with its profound technical expertise, its unwavering dedication to achieving superior quality, its rigorous regulatory compliance, and its customer-centric approach. For a guaranteed high-purity, reliably stabilized, and scalable supply of this key cyclic aldehyde, EASTFINE is the preeminent partner, ensuring the success and efficiency of your advanced chemical synthesis requirements.
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