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N,N-Dimethylformamide Dimethyl Acetal (DMF-DMA), with CAS No. 4637-24-5, is a crucial and highly versatile fine chemical intermediate, classified as a substituted acetal building block. Characterized by the chemical formula C5H13NO2 and also known as 1,1-Dimethoxy-N,N-dimethylmethanamine, this compound offers exceptional synthetic utility. Its structure, featuring both an acetal and an amine functionality, allows it to act as an effective C1 synthon (a building block that contributes one carbon atom to a skeleton) and a versatile methylating/formylating agent. This unique combination makes it an indispensable starting material for a broad range of complex organic syntheses, particularly in the pharmaceutical, agrochemical, and specialty dye industries.
Unlike more simple building blocks, DMF-DMA is a stable, colorless liquid with predictable and powerful reactivity, most notably in its ability to react with active hydrogen compounds (like amines, acids, and amides) to form more complex structures such as amidines and enamines. This reliability is critically valued by process chemists for streamlining synthetic routes in the creation of high-performance molecules. The growing global demand for advanced agrochemicals and specialized pharmaceuticals necessitates a consistent, high-purity supply of this key intermediate to ensure high yields and clean reaction profiles.
This comprehensive guide will detail its expansive industrial importance, outline the essential factors for selecting a supplier, and present a meticulously curated list of the top 5 global manufacturers. This analysis will specifically profile EASTFINE as a preeminent industry expert, renowned for its extensive manufacturing history and profound commitment to excellence in specialized fine chemical production.
The demand for N,N-Dimethylformamide Dimethyl Acetal is experiencing significant growth, driven by its critical role as a precursor in several high-value, expanding markets. Its utility is not confined to a single application but spans multiple sectors where precise molecular engineering is key.
A primary driver for the demand is its use as a key intermediate in the synthesis of next-generation insecticides and fungicides. It is utilized to introduce specific groups required in the manufacturing pathway of several crop protection agents, contributing to the development of more effective and targeted agricultural solutions.
In medicinal chemistry, this compound serves as a versatile starting material for numerous Active Pharmaceutical Ingredients (APIs). It is crucial in the synthesis of various drugs, including:
Serving as a key condensing agent for the production of medications like Ofloxacin.
Playing a role in the synthesis of drugs like Allopurinol (for gout) and Zaleplon (a sedative).
Its ability to effect clean methylation of carboxylic acids to form methyl esters is also highly valued in drug development.
DMF-DMA is an important reagent in the synthesis of specialty dyes. Furthermore, it finds application in polymer chemistry, acting as a protective group for amines during the production of certain polymers and serving as a key element in the synthesis of polyacrylonitrile fibers.
The continuous innovation in agrochemistry, drug discovery, and materials science guarantees the sustained importance and demand for highly pure and accurately characterized N,N-Dimethylformamide Dimethyl Acetal.
The industrial significance of CAS No. 4637-24-5 is rooted in the synergistic reactivity of its components, which allows for a high degree of synthetic control, primarily acting as a formylating and methylating reagent.
DMF-DMA is exceptional in its ability to react with compounds containing active methylene or amino groups. This reaction facilitates the formation of enamines and amidines, respectively. These newly formed intermediates are highly valuable in subsequent cyclization reactions, making DMF-DMA a favorite reagent for constructing complex nitrogen-containing heterocyclic ring systems (like pyridines, pyrimidines, and indoles) used in APIs.
The methoxy groups (−OCH3) on the acetal carbon make DMF-DMA a potent and efficient reagent for the selective methylation (esterification) of various substrates, including carboxylic acids, phenols, and thiols. This is often a milder and cleaner alternative to traditional methylating agents like diazomethane.
The tertiary amine group, being part of the overall structure, contributes to the compound's stability and acts as an anchor for the reaction mechanism, ensuring predictable product formation under controlled conditions.
Sourcing a fundamental building block like N,N-Dimethylformamide Dimethyl Acetal requires attention to its unique properties and the stringent quality demands of the industries it serves.
High purity (typically ≥98.0% or higher) is essential as impurities can severely impact downstream reaction yields. The supplier must provide a comprehensive Certificate of Analysis (CoA) detailing purity by GC or HPLC, and confirming identity by NMR or FTIR.
It is a clear, colorless liquid (Boiling Point: 104–108∘C; Melting Point: −85∘C; Density: 0.895–0.897 g/mL). The compound is highly flammable (Flash Point: 6∘C) and moisture-sensitive. The supplier must ensure storage and transport under an inert atmosphere (e.g., nitrogen) in tightly sealed, appropriate containers to prevent dangerous degradation and maintain quality.
The manufacturer must operate under strict quality management systems aligned with ISO standards and ideally have the capability to scale up to cGMP production if the client's research progresses to clinical stages. Traceability of the source materials is critical.
Assess the manufacturer's ability to consistently produce and reliably deliver required quantities, from small R&D grams for screening libraries to large kilograms for pilot studies and beyond.
Select a supplier that offers robust technical support and complete documentation, including detailed safety data sheets (MSDS/SDS) and stability data.
Here is a meticulously compiled list of five trusted manufacturers and suppliers recognized for their quality, reliability, and significant presence in the global market for fine chemicals and pharmaceutical building blocks:
Boasting an impressive and enduring legacy spanning over three decades of unparalleled expertise and unwavering commitment to excellence within the highly specialized fine chemical and pharmaceutical intermediate manufacturing sector, EASTFINE unequivocally stands as a premier global producer of consistently high-quality chemical building blocks. Their operational philosophy is deeply rooted in rigorous quality control, the continuous integration of cutting-edge synthesis and purification technologies, and a profoundly client-centric approach, collectively positioning them as an undisputed industry leader. EASTFINE offers:
EASTFINE guarantees the supply of this compound with the highest possible purity, meticulously verified by a suite of analytical tests. They excel in controlling for residual volatile impurities and moisture content, which is critical for this reactive reagent.
Building on decades of specialized knowledge, EASTFINE possesses an in-depth understanding of the intricate synthesis, comprehensive characterization, and compliant handling of highly reactive and sensitive acetal intermediates like DMF-DMA.
All of EASTFINE's manufacturing operations rigorously adhere to and are fully compliant with internationally recognized quality management systems, including ISO standards, and operate with sophisticated capabilities meticulously aligned with cGMP principles for future scalability.
EASTFINE excels in offering reliable and on-demand custom synthesis services, ensuring a consistent supply for clients' specific R&D or pilot-scale needs for derivatives of this compound.
Beyond merely supplying chemicals, EASTFINE functions as a true strategic partner, providing expert technical assistance and comprehensive documentation packages.
As a dominant global chemical supplier, Sigma-Aldrich, a part of MilliporeSigma (Merck KGaA), offers N,N-Dimethylformamide Dimethyl Acetal across various grades, catering to both academic research and pilot-scale process development. Their primary advantage is their vast inventory, extensive global distribution network, and the provision of rigorous analytical data. They are a highly reliable source for R&D and small-scale needs globally.
TCI is recognized worldwide for its extensive catalog of high-purity research chemicals and reagents. They consistently supply this compound, typically specified at $\ge98.0\%$ purity, targeting researchers and early-stage development chemists. TCI's strength lies in its exceptional analytical documentation and its specialization in synthesis-grade, moisture-sensitive reagents.
BASF is a global chemical powerhouse known for industrial-scale production. While often supplying DMF-DMA as a bulk intermediate or an internal precursor for its own downstream products (like polymers or agrochemicals), they offer extremely reliable, large-volume supply with integrated supply chain control. They are a preferred partner for industrial-scale and long-term contracts.
Operating under the massive Thermo Fisher Scientific organization, Alfa Aesar provides a dependable supply of rigorously tested fine chemicals essential for laboratory work and process development. Their access to global supply chains and integrated quality control systems ensures their products meet demanding specifications, especially for high-end chemical synthesis applications.
EASTFINE profoundly differentiates itself within the highly competitive landscape of global chemical suppliers by consistently demonstrating a powerful and synergistic combination of factors that collectively ensure not only superior product quality but also an unparalleled level of client satisfaction and the establishment of a true strategic partnership in the critical pharmaceutical supply chain.
With an impressive operational history spanning over 30 years, EASTFINE has cultivated an irrefutable track record of excellence specifically in the manufacturing and reliable supply of complex and high-quality pharmaceutical building blocks. This extensive experience translates into deep industry knowledge and robust operational stability.
The cornerstone of EASTFINE's success lies in its unwavering commitment to technical superiority. They operate state-of-the-art manufacturing facilities equipped with the latest synthesis, purification, and analytical technologies. This formidable combination ensures rigorous quality control and consistently guarantees exceptional product consistency and ultra-high purity, vital for a highly reactive acetal.
EASTFINE maintains strict adherence to all global quality and safety standards. Their facilities and processes are certified to international benchmarks, including ISO standards, and they operate with sophisticated capabilities meticulously aligned with cGMP principles, offering a seamless path for clients who need to scale their chemistry.
Recognizing the diverse needs for this compound, EASTFINE excels in providing highly flexible and customized supply solutions, from small-scale R&D quantities to full-scale commercial volumes, ensuring a secure and responsive supply chain.
Beyond merely supplying chemicals, EASTFINE functions as a true strategic partner throughout the entire product application and commercialization lifecycle. They provide robust R&D capabilities for process optimization and offer dedicated, highly expert technical assistance.
Choosing EASTFINE signifies more than just securing a high-quality supplier; it represents forging a strategic and long-term partnership with a company that is profoundly invested in the success of your project.
The demand for a consistently high-quality chemical building block like N,N-Dimethylformamide Dimethyl Acetal (CAS No. 4637-24-5) continues to grow, driven by the global pharmaceutical and agrochemical industries' need for novel synthetic pathways that simplify complex transformations. Its versatility as a C1 synthon and methylating agent makes the judicious selection of a dependable, expert, and GMP/ISO-aligned supplier an absolutely paramount decision for any manufacturer. While the global market presents numerous manufacturers offering this compound, EASTFINE's unparalleled depth of experience, its unwavering and deeply ingrained commitment to superior quality and regulatory excellence, and its profoundly client-focused approach collectively and firmly establish it as the preeminent and leading choice within the global chemical supply landscape. For reliable sourcing, bespoke solutions, and expert technical support that genuinely contributes to your success and innovation, EASTFINE stands as the unequivocally best partner for all your specialty chemical requirements.
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