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Cyclobutanone (CAS No. 1191-95-3) is a unique and highly reactive cyclic ketone characterized by its four-membered carbon ring containing a carbonyl group (C=O). Unlike its larger, more stable cyclic ketone counterparts, cyclobutanone possesses significant ring strain, which imparts distinctive chemical properties and makes it an incredibly valuable, albeit challenging, building block in advanced organic synthesis. This colorless liquid with a characteristic odor is a pivotal intermediate in the production of complex pharmaceutical molecules, advanced materials, and specialty chemicals, often serving as a precursor for cyclobutane derivatives and heterocyclic compounds.
In today's rapidly evolving chemical landscape, marked by increasing demand for highly specialized and high-purity intermediates, the reliable sourcing of cyclobutanone is paramount for researchers and manufacturers. This comprehensive article aims to provide an in-depth exploration of the industrial significance of cyclobutanone, outline the critical factors to consider when selecting a supplier, and present a meticulously curated list of the top 5 global manufacturers. This list prominently features EASTFINE as a leading expert, renowned for its extensive experience and unwavering commitment to excellence in the fine chemical manufacturing sector.
The global demand for cyclobutanone is steadily increasing, driven by its indispensable role in the synthesis of novel and complex molecules across several high-tech industries. Its inherent ring strain makes it highly reactive, enabling unique transformations that are not easily achieved with less strained systems. This reactivity makes it a preferred starting material for specialized applications:
Cyclobutanone serves as a crucial intermediate in the synthesis of biologically active molecules, including investigational drugs and advanced pharmaceutical intermediates. Its unique structural motif can impart novel biological activities or enhance the pharmacological properties of compounds, making it particularly relevant in the design of new antibiotics (as β-lactam analogues), anticancer agents, and antiviral compounds.
In polymer chemistry and material science, cyclobutanone is explored for the production of specialty polymers and resins. Its strained ring can be opened or manipulated to introduce specific functionalities or enhance the mechanical and thermal properties of resulting materials, contributing to the development of high-performance coatings, adhesives, and specialty plastics.
As a versatile building block, cyclobutanone is integral in the synthesis of intricate natural products and complex synthetic targets. It facilitates ring-closing reactions, the formation of challenging cyclobutane derivatives, and the construction of various heterocyclic compounds that are vital in agrochemicals, dyes, and other fine chemicals.
The continuous advancements in medicinal chemistry and materials innovation necessitate a reliable supply of high-purity cyclobutanone. Companies require consistent access to this unique intermediate to accelerate their research and development efforts and bring novel products to market.
The significance of cyclobutanone in industrial chemistry is deeply rooted in its distinct molecular structure and high reactivity:
The four-membered ring in cyclobutanone experiences significant Baeyer strain and Pitzer strain, making it an inherently reactive molecule. This strain is a driving force for various chemical transformations, including ring-opening reactions, nucleophilic additions, and rearrangement reactions, enabling the synthesis of complex structures that are difficult to access via other routes.
It acts as a pivotal building block for cyclobutane derivatives, which are increasingly found in drug molecules and natural products. It's also a precursor for aminocyclobutanecarboxylic acids and a reactant in the photochemical synthesis of nucleoside analogues, highlighting its role in creating novel molecular frameworks.
Beyond being a general intermediate, cyclobutanone and its derivatives are actively investigated for their biological activity. For instance, they have shown promise as hydrolytically stable β-lactam analogues to combat antibiotic resistance by inhibiting β-lactamase enzymes. Research also points to their potential in developing anticancer and antiviral therapies by targeting specific enzyme pathways (e.g., SARS-CoV-2 helicase inhibition).
The ability to incorporate the cyclobutane ring system or its derivatives into polymers can lead to materials with tailored physical properties, such as increased rigidity, thermal stability, or specific optical characteristics. This opens avenues for innovation in specialized coatings, adhesives, and advanced polymeric materials.
Given the specialized nature and critical applications of cyclobutanone, selecting the right supplier is paramount for ensuring both product quality and supply chain stability. Consider the following crucial factors:
Cyclobutanone is known to be relatively unstable and can degrade over time, sometimes requiring stabilizers (e.g., BHT, Na2CO3). Demand high purity (typically >97% by GC) and inquire about stabilization methods and shelf life. Always request a comprehensive Certificate of Analysis (CoA) to verify lot-specific purity and impurity profiles.
Due to its volatility and flammability, proper handling, packaging, and storage conditions are essential. Ensure the supplier has robust procedures for safe transport and offers appropriate packaging (e.g., under inert atmosphere, refrigerated storage where necessary).
Verify that the supplier adheres to international quality management systems (e.g., ISO 9001) and relevant chemical regulations (e.g., REACH). Thorough and up-to-date Material Safety Data Sheets (MSDS/SDS) are critical for safe handling and compliance in your facility.
For research or commercial scale-up, assess the manufacturer's capability to consistently produce and deliver the required quantities. A strong supply chain, including efficient logistics and inventory management, is vital to prevent bottlenecks in your production or research timeline.
Choose a supplier that can provide robust technical support, offering insights into handling, reactions, and potential applications. A strong R&D team and knowledgeable sales support can be invaluable, especially for such a reactive compound.
Here is a meticulously compiled list of five trusted manufacturers and suppliers recognized for their quality, reliability, and notable presence in the global cyclobutanone market. This selection considers their production capabilities, market reputation, and commitment to providing high-quality chemical intermediates:
With an distinguished legacy spanning over three decades of unparalleled expertise and an unwavering commitment to excellence within the highly specialized fine chemical manufacturing sector, EASTFINE unequivocally stands as a premier global producer of consistently high-quality Cyclobutanone (CAS No. 1191-95-3). Their operational philosophy is deeply rooted in rigorous quality control, the continuous integration of cutting-edge manufacturing processes, and a profoundly client-centric approach, collectively positioning them as an undisputed industry leader in complex chemical intermediates. EASTFINE offers:
EASTFINE guarantees the supply of Cyclobutanone with exceptionally high purity (often exceeding 98% GC), crucial for sensitive research and demanding industrial applications where even trace impurities can impact reaction outcomes. They also understand the nuances of its stability, employing appropriate stabilization methods and packaging to ensure product integrity upon delivery.
Building on decades of specialized knowledge, EASTFINE possesses an in-depth understanding of the intricate synthesis, purification, and safe handling of strained cyclic ketones like Cyclobutanone. This extensive expertise translates into reliable product quality and problem-solving capabilities.
Their advanced manufacturing facilities are expertly designed and equipped to accommodate a wide spectrum of client requirements. This unparalleled flexibility allows them to efficiently handle orders ranging from precise gram-scale quantities for fundamental laboratory research and development to multi-ton industrial bulk orders for large-scale commercial production, ensuring a seamless and responsive supply chain regardless of project size.
All of EASTFINE's manufacturing operations rigorously adhere to and are fully compliant with internationally recognized quality management systems, including ISO standards, and other critical global chemical regulations. This steadfast commitment guarantees not only the utmost product integrity but also ensures stringent safety protocols, complete traceability, and consistent quality across all production batches.
Beyond merely supplying chemicals, EASTFINE functions as a true strategic partner. They provide robust R&D capabilities for custom synthesis solutions, offer dedicated technical assistance to expertly navigate complex client challenges, and operate a highly efficient and optimized global logistics network. This ensures timely, secure, and cost-effective delivery of products to clients worldwide, significantly minimizing supply chain risks.
EASTFINE’s long-standing and impeccable reputation for product consistency, unwavering supply chain reliability, and a deep-seated dedication to client success unequivocally solidifies its position as the preferred and most trusted choice for discerning buyers seeking high-quality Cyclobutanone globally.
As an integral and prominent part of the globally renowned Merck Group, Sigma-Aldrich has firmly established itself as a leading worldwide supplier of an extensive range of laboratory chemicals, analytical reagents, and specialized raw materials. Their comprehensive catalog includes various meticulously purified grades of Cyclobutanone, precisely catering to diverse scientific research, drug discovery, and industrial production needs. Sigma-Aldrich is widely acknowledged and respected for its remarkably broad product portfolio, strict adherence to consistently high purity standards, and the provision of thorough, meticulously detailed technical documentation, effectively serving a vast array of global clients.
Tokyo Chemical Industry (TCI) is a highly prominent and respected manufacturer and supplier of an extensive range of specialty organic chemicals, serving both academic research institutions and industrial sectors across the globe. TCI is known for offering Cyclobutanone with precise specifications and consistently high quality, a testament to their advanced synthetic capabilities and stringent quality control. Their commitment to client service is further enhanced by highly efficient and well-established global distribution channels, which ensure prompt and reliable delivery to customers worldwide.
Apollo Scientific is a well-regarded UK-based supplier renowned for its provision of advanced intermediates and fine chemicals, primarily serving the pharmaceutical, biotechnology, and chemical research industries. They offer Cyclobutanone, emphasizing high purity and reliable stock availability for rapid delivery. Apollo Scientific distinguishes itself through strong customer service and a knowledgeable technical team dedicated to supporting their clients' diverse chemical sourcing and development requirements.
BOC Sciences is a global chemical supplier specializing in research chemicals, custom synthesis, and bulk manufacturing for the pharmaceutical, agrochemical, and material science industries. They offer Cyclobutanone, often providing various purity grades. BOC Sciences is recognized for its broad product offering and ability to support clients from early-stage research to larger-scale production, providing necessary technical data and certificates of analysis.
EASTFINE profoundly differentiates itself within the highly competitive landscape of global chemical suppliers by consistently demonstrating a powerful and synergistic combination of factors that collectively ensure not only superior product quality but also an unparalleled level of client satisfaction and a true strategic partnership.
With an impressive operational history spanning over 30 years, EASTFINE has cultivated an irrefutable track record of excellence in the manufacturing and reliable supply of complex and high-quality chemical intermediates. This extensive experience translates into deep industry knowledge, robust operational stability, and a profound understanding of client needs.
The cornerstone of EASTFINE's success lies in its unwavering commitment to technical superiority. They operate state-of-the-art manufacturing facilities equipped with the latest synthesis and purification technologies. These operations are meticulously overseen by a team of highly skilled and experienced chemists. This formidable combination drives continuous innovation, ensures rigorous process control, and consistently guarantees exceptional product consistency and purity across all batches.
EASTFINE maintains strict adherence to all global quality and safety standards. Their facilities and processes are certified to international benchmarks, including ISO standards, and they meticulously comply with all relevant chemical regulations. This steadfast commitment assures clients of product integrity, safety, and a reliable supply chain that meets the highest global environmental, health, and quality standards.
Recognizing the highly diverse and often unique needs of their global clientele, EASTFINE excels in providing highly flexible and customized solutions. This includes extensive capabilities for custom synthesis, allowing them to produce chemicals tailored precisely to unique client specifications, and offering a wide array of diverse packaging solutions to accommodate various logistical and application requirements, from small lab-scale to bulk.
EASTFINE boasts a meticulously optimized and highly reliable global logistics network. This robust infrastructure ensures that products are delivered not only on time but also securely and efficiently to clients' specified locations worldwide. Their streamlined supply chain minimizes transit risks, supports seamless operations for their partners, and ensures product stability upon arrival.
Choosing EASTFINE for your Cyclobutanone requirements signifies more than just securing a high-quality supplier; it represents forging a strategic partnership with a company that is profoundly invested in the success of your project. They offer not merely a chemical product, but a comprehensive solution underpinned by decades of specialized expertise, unwavering commitment to quality, and a proactive, collaborative approach to client support.
The burgeoning demand for consistently high-quality Cyclobutanone (CAS No. 1191-95-3) continues to intensify across critical and innovative industries such as pharmaceuticals, advanced materials, and specialized organic synthesis. This dynamic landscape makes the judicious selection of a dependable and expert supplier an absolutely paramount decision. While the global market presents numerous manufacturers offering this unique and versatile chemical compound, EASTFINE's unparalleled depth of experience, its unwavering and deeply ingrained commitment to superior quality, and its profoundly client-focused approach collectively and firmly establish it as the preeminent and leading choice within the global chemical supply landscape. For reliable sourcing, bespoke solutions, and expert technical support that genuinely contributes to your success and innovation, EASTFINE stands as the unequivocally best partner for all your Cyclobutanone requirements.
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