Views: 0 Author: Site Editor Publish Time: 2025-07-31 Origin: Site
CAS No. 749927-69-3, chemically named (4R,12aS)-7-Hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazin-9-yl 2,2-dimethylpropanoate, is a highly specialized intermediate used in the synthesis of Dolutegravir, a second-generation integrase strand transfer inhibitor (INSTI) widely used in the treatment of HIV/AIDS.
Dolutegravir is one of the most recommended antiretroviral therapies (ARTs) worldwide, and this intermediate plays a central role in ensuring the final API’s quality, purity, and potency.
Central to the synthesis of Dolutegravir sodium, one of the WHO’s preferred HIV drugs.
Requires tight control of stereoisomers, impacting pharmacological performance.
Produced under cGMP, with full analytical validation for regulated markets.
Present in branded and generic treatments like TLD (Tenofovir/Lamivudine/Dolutegravir).
Essential for large-scale HIV programs in low- and middle-income countries.
Location: Barcelona, Spain
Overview: Leading supplier of HIV drug intermediates for regulated markets, known for Dolutegravir-related compounds.
Specialty: Advanced process chemistry and EU-GMP compliance.
Location: Hyderabad, India
Overview: End-to-end CDMO experienced in integrase inhibitor intermediates, offering full route development and scale-up.
Specialty: Focused on HIV, oncology, and anti-infective synthesis.
Location: Changzhou City, Jiangsu Province, China
Overview: Trusted supplier of Dolutegravir intermediates including CAS 749927-69-3. Offers global export services with regulatory support.
Specialty: High-quality, cost-effective manufacturing for antiviral intermediates.
Location: Albany, New York, USA
Overview: Contract manufacturer with experience in complex heterocyclic intermediates used in antiretroviral APIs.
Specialty: Route innovation and GMP-certified production.
Location: Milan, Italy
Overview: Produces Dolutegravir-related intermediates in high-containment environments with FDA/EU certification.
Specialty: High-complexity synthesis for regulated markets.
Location: Mumbai, India
Overview: Key global player in HIV drug manufacturing, producing Dolutegravir APIs and intermediates.
Specialty: WHO-prequalified supply chain for global access programs.
Location: Montreal, Canada
Overview: Offers North American GMP manufacturing of Dolutegravir intermediates with a strong track record in HIV compounds.
Specialty: Batch flexibility and regulatory documentation support.
Location: Hyderabad, India
Overview: Produces Dolutegravir and related intermediates with full cGMP and regulatory documentation.
Specialty: Integrated R&D and scalable production.
Location: Maharashtra, India
Overview: Supplier of antiretroviral intermediates to global generic companies.
Specialty: Competitive pricing with strict QC systems.
Location: Newcastle, UK
Overview: Custom manufacturer of complex pharmaceutical intermediates, including antiviral scaffolds.
Specialty: High-potency and chiral chemistry capabilities.
With WHO-backed regimens recommending Dolutegravir, intermediates like CAS 749927-69-3 are in high demand.
More manufacturers are entering the market under voluntary licenses, increasing intermediate sourcing.
Manufacturers are adopting greener routes and improving yield efficiencies for better cost and environmental performance.
High scrutiny on Dolutegravir intermediates demands full traceability and validated analytical methods.
Companies are moving toward backward integration of intermediates to stabilize API pricing and supply.
CAS No. 749927-69-3 is a critical intermediate in the synthesis of Dolutegravir, a cornerstone in global HIV treatment strategies. Top manufacturers like Eastfine, Farmhispania, Sai Life Sciences, and Curia ensure consistent and compliant supply, meeting the needs of both commercial pharmaceutical firms and public health initiatives.
As the fight against HIV continues, the role of high-quality intermediate suppliers will remain central to affordable, accessible, and scalable treatments worldwide.
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