Top 10 Manufacturers of Pharmaceutical Intermediate CAS No. 654-70-6 in 2025

Understanding 1,3-Dichloropropane (CAS No. 654-70-6)

1,3-Dichloropropane (CAS No. 654-70-6) is an essential chemical intermediate used in the synthesis of various pharmaceutical products. This compound, a colorless liquid with a sharp odor, is widely utilized in the production of pesticides and other chemicals but also plays a role in pharmaceutical applications, particularly in the synthesis of specific APIs (Active Pharmaceutical Ingredients).

As a key building block in pharmaceutical manufacturing, 1,3-Dichloropropane aids in producing drugs that target various medical conditions, from bacterial infections to cancer treatments. The purity and consistency of 1,3-Dichloropropane are critical in ensuring that drugs made from it meet stringent safety and efficacy standards.

Importance of 1,3-Dichloropropane in Drug Development

Drug Synthesis and Research:

1,3-Dichloropropane is used in the creation of certain APIs that serve as the backbone for various pharmaceutical products. Its versatility makes it essential for developing medications used to treat a range of conditions, including infections and neurological diseases.

Cost-Efficient Manufacturing:

By using intermediates like 1,3-Dichloropropane, pharmaceutical manufacturers can streamline their processes, reduce manufacturing complexities, and achieve cost savings in the production of APIs. This ultimately benefits patients through more affordable medication.

Regulatory Compliance:

The production of 1,3-Dichloropropane must comply with global regulatory standards such as Good Manufacturing Practices (GMP) to ensure its safety and efficacy in pharmaceutical formulations.

Scalability and Versatility:

1,3-Dichloropropane is useful in large-scale production, which helps meet global demand for pharmaceuticals while maintaining the required purity and quality. Its applications are wide-ranging, supporting both generics and branded pharmaceutical products.

Top 10 Manufacturers of 1,3-Dichloropropane (CAS No. 654-70-6)

1. Lonza Group

• Location: Basel, Switzerland

• Overview: Lonza, a major player in the pharmaceutical and biotechnology sectors, produces a wide array of pharmaceutical intermediates, including 1,3-Dichloropropane. Their contract development and manufacturing services span the entire pharmaceutical lifecycle.

• Key Products: Biopharmaceutical manufacturing, APIs for oncology, immunology, and other therapeutic areas.

2. BASF

• Location: Ludwigshafen, Germany

• Overview: BASF is one of the largest chemical companies in the world, offering a range of high-quality pharmaceutical intermediates, including 1,3-Dichloropropane. Their commitment to advanced chemical manufacturing ensures regulatory compliance and product safety.

• Key Products: Pharmaceutical intermediates, fine chemicals, custom synthesis for various therapeutic areas.

3. Eastfine

• Location: Changzhou City, Jiangsu Province, China

• Overview: Eastfine is a leading Chinese manufacturer of pharmaceutical intermediates, including 1,3-Dichloropropane. The company specializes in cost-effective, high-quality solutions and operates under stringent international regulatory standards.

• Key Products: Intermediates for generics and branded drugs, fine chemicals for industrial applications.

4. Evonik Industries

• Location: Essen, Germany

• Overview: Evonik is an international leader in specialty chemicals and pharmaceuticals. The company is involved in the production of intermediates like 1,3-Dichloropropane, which are essential in the synthesis of both generic and innovative drugs.

• Key Products: Custom synthesis services, APIs, and intermediates for pharmaceutical applications.

5. Mitsubishi Chemical Corporation

• Location: Tokyo, Japan

• Overview: Mitsubishi Chemical is a major player in the chemical and pharmaceutical sectors, producing intermediates like 1,3-Dichloropropane. Their expertise in sustainable manufacturing practices and innovative chemical processes makes them a trusted partner for pharmaceutical companies.

• Key Products: Pharmaceutical intermediates, high-purity APIs for various therapeutic categories.

6. Syngene International

• Location: Bangalore, India

• Overview: Syngene is a prominent contract research and manufacturing organization (CRMO) that offers custom synthesis services, including for 1,3-Dichloropropane. Their comprehensive services span drug discovery, development, and commercial production.

• Key Products: Custom synthesis of intermediates and APIs for pharmaceutical companies.

7. Cambrex Corporation

• Location: East Rutherford, New Jersey, USA

• Overview: Cambrex provides comprehensive manufacturing services, including the production of 1,3-Dichloropropane for the pharmaceutical industry. The company specializes in high-quality APIs and intermediates used in drug development and commercialization.

• Key Products: Custom synthesis, small molecule APIs, and pharmaceutical intermediates.

8. Sandoz (Novartis Division)

• Location: Holzkirchen, Germany

• Overview: Sandoz, a leader in the generics sector, produces a variety of pharmaceutical intermediates, including 1,3-Dichloropropane. Their expertise in manufacturing complex drugs helps make essential treatments more affordable and accessible worldwide.

• Key Products: Intermediates for generics, biosimilars, and injectable drugs.

9. Cipla

• Location: Mumbai, India

• Overview: Cipla is a globally recognized pharmaceutical company specializing in the production of generics. The company manufactures high-quality 1,3-Dichloropropane to serve various therapeutic needs, particularly in oncology and respiratory diseases.

• Key Products: Generics, APIs, and intermediates for a wide range of therapeutic applications.

10. Mylan Pharmaceuticals (now part of Viatris)

• Location: Canonsburg, Pennsylvania, USA

• Overview: Mylan, now part of Viatris, is a major global generics player. The company manufactures pharmaceutical intermediates such as 1,3-Dichloropropane, supporting a broad range of therapeutic areas.

• Key Products: Generic APIs, intermediates, and contract manufacturing services.

Trends in the Pharmaceutical Intermediates Market

Growing Demand for Generic Drugs:

The increasing demand for generics and cost-effective treatments is driving the market for intermediates like 1,3-Dichloropropane. As more regions, particularly emerging markets, push for access to affordable medications, intermediates play a key role in drug manufacturing.

Advancements in Green Chemistry:

The pharmaceutical sector is focused on reducing its environmental impact. Green chemistry and sustainable practices are being integrated into the production of intermediates like 1,3-Dichloropropane, ensuring that drug manufacturing is more eco-friendly and cost-effective.

Regulatory Scrutiny:

As regulatory requirements become stricter worldwide, pharmaceutical companies must ensure that intermediates like 1,3-Dichloropropane are produced to meet compliance standards. This is driving investment in better manufacturing technologies and quality control processes.

Rise of Personalized Medicine:

The increasing emphasis on personalized medicine is driving demand for specialized intermediates like 1,3-Dichloropropane that can be used in the production of tailored therapies, particularly in oncology and immunotherapy.

Conclusion

1,3-Dichloropropane (CAS No. 654-70-6) is a vital pharmaceutical intermediate that plays a crucial role in the synthesis of various therapeutic drugs. From generics to complex biologics, its importance in drug manufacturing is undeniable.

The companies listed above—Lonza, BASF, Eastfine, Mitsubishi Chemical, and others—are at the forefront of producing high-quality 1,3-Dichloropropane, helping the pharmaceutical industry meet global demands for safe, effective, and affordable medications. With increasing focus on sustainability, innovation, and regulatory compliance, the market for pharmaceutical intermediates will continue to evolve, and companies that embrace these trends will be positioned for future growth.