Top 10 Manufacturers of Pharmaceutical Intermediate CAS No. 6291-84-5 in 2025

Understanding 3-(Trifluoromethyl)-5-(trifluoromethylthio)-benzoic acid (CAS No. 6291-84-5)

3-(Trifluoromethyl)-5-(trifluoromethylthio)-benzoic acid (CAS No. 6291-84-5) is a versatile pharmaceutical intermediate known for its trifluoromethyl and trifluoromethylthio substituents. These functional groups make the compound particularly useful in the synthesis of bioactive molecules with high chemical stability and potent pharmacological effects. This intermediate is commonly used in the development of anti-inflammatory, antiviral, and other therapeutic agents.

Its unique molecular structure also contributes to its utility in agrochemicals and specialty chemicals, as it enhances the bioavailability and potency of various drug formulations. Manufacturers rely on this intermediate for the production of high-quality APIs in both clinical development and commercial manufacturing.

Importance of 3-(Trifluoromethyl)-5-(trifluoromethylthio)-benzoic acid in Drug Development

Anti-inflammatory Applications:

Due to its structural features, this intermediate plays a vital role in creating anti-inflammatory drugs. Its trifluoromethyl groups are known to improve the metabolic stability of pharmaceutical agents, enhancing their effectiveness in treating inflammatory diseases.

Antiviral Properties:

The compound’s ability to modulate certain enzymes makes it useful in developing antiviral drugs. It is commonly involved in the synthesis of compounds that target viral replication, particularly in the context of respiratory and gastrointestinal infections.

Enhanced Drug Bioavailability:

The trifluoromethyl and trifluoromethylthio groups increase the lipophilicity of the final compound, which can help improve drug absorption and bioavailability. This is essential for ensuring that drugs are effectively delivered to their intended sites of action.

Regulatory Compliance and GMP Standards:

Manufacturing intermediates like CAS 6291-84-5 must meet stringent regulatory standards, including GMP (Good Manufacturing Practices) and ICH (International Council for Harmonisation) guidelines, to ensure the safety, efficacy, and quality of the final pharmaceutical products.

Scalability and Cost-Effective Production:

The scalability of this intermediate ensures that pharmaceutical companies can meet increasing market demand while maintaining cost-effectiveness. Its production can be scaled up from research to commercial manufacturing without compromising quality.

Top 10 Manufacturers of CAS No. 6291-84-5

1. Lonza Group

• Location: Basel, Switzerland

• Overview: Lonza is a global leader in the production of pharmaceutical intermediates and APIs. The company offers high-quality synthesis services for complex compounds like 3-(Trifluoromethyl)-5-(trifluoromethylthio)-benzoic acid, ensuring compliance with international regulatory standards.

• Specialty: Custom synthesis, biopharmaceutical manufacturing, and API production.

2. BASF

• Location: Ludwigshafen, Germany

• Overview: BASF is a world-renowned chemical manufacturer with a broad portfolio that includes pharmaceutical intermediates. Their cutting-edge technologies in fluorine chemistry make them a leader in providing high-quality intermediates like CAS 6291-84-5 for pharmaceutical applications.

• Specialty: Advanced chemical manufacturing and sustainable synthesis.

3. Eastfine

• Location: Changzhou City, Jiangsu Province, China

• Overview: Eastfine is an established manufacturer of pharmaceutical intermediates, including CAS 6291-84-5. The company is known for its commitment to quality, efficient production, and adherence to global regulatory standards, making it a preferred supplier for pharmaceutical companies worldwide.

• Specialty: High-purity intermediates for anti-inflammatory and antiviral drugs.

4. Almac Group

• Location: Craigavon, United Kingdom

• Overview: Almac specializes in providing custom manufacturing services for complex pharmaceutical intermediates like 3-(Trifluoromethyl)-5-(trifluoromethylthio)-benzoic acid. Their expertise in drug development and GMP compliance ensures the production of high-quality intermediates for clinical trials and commercial manufacturing.

• Specialty: Custom synthesis and oncology-focused synthesis services.

5. Syngene International

• Location: Bangalore, India

• Overview: Syngene is a trusted CDMO that supports the pharmaceutical industry with integrated research and manufacturing services. They provide high-quality production of intermediates such as CAS 6291-84-5, particularly for antiviral and anti-inflammatory applications.

• Specialty: API synthesis, process development, and scale-up manufacturing.

6. Mitsubishi Chemical Corporation

• Location: Tokyo, Japan

• Overview: Mitsubishi Chemical is a leading supplier of pharmaceutical intermediates, including CAS 6291-84-5. Their advanced fluorine chemistry capabilities allow them to produce intermediates with high purity and stability.

• Specialty: High-performance fluorine-based intermediates.

7. Evonik Industries

• Location: Essen, Germany

• Overview: Evonik provides a wide range of chemical and pharmaceutical intermediates. The company’s expertise in fluorine chemistry enables them to manufacture CAS 6291-84-5 efficiently, ensuring high standards for global pharmaceutical applications.

• Specialty: Pharmaceutical intermediates, green chemistry, and sustainable manufacturing.

8. Siegfried Holding AG

• Location: Zofingen, Switzerland

• Overview: Siegfried is a global leader in contract manufacturing, specializing in both the production and development of active pharmaceutical ingredients. They manufacture 3-(Trifluoromethyl)-5-(trifluoromethylthio)-benzoic acid for use in various therapeutic applications, particularly in antiviral drug synthesis.

• Specialty: Custom synthesis, advanced pharmaceutical manufacturing.

9. Cambrex Corporation

• Location: East Rutherford, New Jersey, USA

• Overview: Cambrex specializes in the development and manufacturing of small molecule APIs and intermediates. Their expertise in scaling up complex intermediates like CAS 6291-84-5 supports pharmaceutical companies in developing cutting-edge therapies.

• Specialty: Custom API manufacturing and regulatory support services.

10. Teva Pharmaceutical Industries

• Location: Petah Tikva, Israel

• Overview: Teva is one of the largest manufacturers of generic drugs and APIs globally. The company manufactures intermediates like CAS 6291-84-5 for antiviral and anti-inflammatory drug production, providing cost-effective solutions for generic drug development.

• Specialty: Generic drugs, cost-effective manufacturing, and large-scale API production.

Trends in the Pharmaceutical Intermediates Market

Increased Focus on Fluorine Chemistry:

The demand for fluoro-substituted compounds, like CAS 6291-84-5, is growing due to their ability to enhance the stability and bioactivity of drugs. Pharmaceutical companies are investing in advanced fluorine chemistry to support the development of next-generation therapeutics.

Rising Demand for Antiviral and Anti-inflammatory Drugs:

The ongoing global health challenges have accelerated the development of antiviral and anti-inflammatory drugs. Intermediates like CAS 6291-84-5 play a crucial role in ensuring the production of effective therapies to combat infectious and chronic inflammatory diseases.

Sustainability and Green Manufacturing:

There is a growing emphasis on sustainable practices in pharmaceutical manufacturing. Companies are adopting green chemistry approaches, such as using renewable energy and minimizing waste, in the production of intermediates like CAS 6291-84-5.

Collaborations with CDMOs for Complex Intermediates:

Pharmaceutical companies are increasingly turning to contract development and manufacturing organizations (CDMOs) for the production of complex intermediates. This helps accelerate the drug development process while ensuring compliance with regulatory standards.

Conclusion

3-(Trifluoromethyl)-5-(trifluoromethylthio)-benzoic acid (CAS No. 6291-84-5) is a crucial pharmaceutical intermediate in the development of antiviral and anti-inflammatory drugs. Leading manufacturers such as Lonza, BASF, Eastfine, and Mitsubishi Chemical are ensuring the high-quality production of this important compound.

As demand for specialized therapeutic agents grows, particularly in the fight against infectious and chronic diseases, the role of intermediates like CAS 6291-84-5 will only continue to expand, pushing the pharmaceutical industry toward more innovative and effective treatments.