Top 10 Manufacturers of Pharmaceutical Intermediate CAS No. 4271-96-9 in 2025

Understanding 2-Amino-5-Chloropyridine (CAS No. 4271-96-9)

2-Amino-5-chloropyridine, identified by CAS No. 4271-96-9, is a key pharmaceutical intermediate used in the synthesis of various active pharmaceutical ingredients (APIs). It is particularly valuable in the production of medications for conditions such as cancer, inflammation, and certain neurological disorders. As a crucial building block in the drug manufacturing process, 2-Amino-5-chloropyridine ensures that the final drug product is of high quality, effective, and safe for patients.

The compound’s role in the pharmaceutical industry is indispensable as it helps to streamline drug development, reduce manufacturing costs, and meet regulatory requirements for drug safety and efficacy.

Importance of 2-Amino-5-Chloropyridine in Drug Development

Drug Development and Research:

2-Amino-5-chloropyridine plays an essential role in the synthesis of APIs, especially in the fields of oncology and anti-inflammatory treatments. Its ability to facilitate the creation of key therapeutic compounds makes it an invaluable resource in the early stages of drug development.

Cost-Effective Production:

Pharmaceutical companies leverage intermediates like 2-Amino-5-chloropyridine to optimize their manufacturing processes, resulting in cost reductions for API production. This ultimately leads to more affordable drugs for patients.

Regulatory Compliance:

The quality and purity of 2-Amino-5-chloropyridine are critical to meeting regulatory standards set by agencies such as the FDA and EMA. Adherence to Good Manufacturing Practices (GMP) ensures the safety and reliability of the final pharmaceutical products.

Scalability and Versatility:

2-Amino-5-chloropyridine supports large-scale drug production without compromising purity or quality. Its versatility makes it suitable for use in the production of a wide range of pharmaceutical products across different therapeutic areas.

Top 10 Manufacturers of 2-Amino-5-Chloropyridine (CAS No. 4271-96-9)

1. Lonza Group

• Location: Basel, Switzerland

• Overview: Lonza is a leader in contract development and manufacturing (CDMO) and produces a broad range of pharmaceutical intermediates, including 2-Amino-5-chloropyridine. The company is renowned for its expertise in both biologics and small molecule drug production.

• Key Products: Biopharmaceutical manufacturing, API production, oncology, and immunology drugs.

2. BASF

• Location: Ludwigshafen, Germany

• Overview: BASF is a global chemical powerhouse, and its pharmaceutical division produces high-quality intermediates such as 2-Amino-5-chloropyridine. BASF’s focus on advanced chemical manufacturing ensures the purity and consistency required for pharmaceutical production.

• Key Products: Pharmaceutical intermediates, fine chemicals, and excipients for drug formulations.

3. Eastfine

• Location: Changzhou City, Jiangsu Province, China

• Overview: Eastfine is a prominent Chinese manufacturer of pharmaceutical intermediates, including 2-Amino-5-chloropyridine. The company is known for producing cost-effective solutions while adhering to strict quality standards, offering a strong commitment to sustainability and global compliance.

• Key Products: Intermediates for generic and branded drugs, fine chemicals for industrial applications.

4. Evonik Industries

• Location: Essen, Germany

• Overview: Evonik is a global leader in specialty chemicals, and it manufactures intermediates such as 2-Amino-5-chloropyridine. Their focus on innovation and sustainability positions them as a key player in the pharmaceutical supply chain.

• Key Products: Custom synthesis of active pharmaceutical ingredients and intermediates, particularly for the pharmaceutical and biotechnology industries.

5. Mitsubishi Chemical Corporation

• Location: Tokyo, Japan

• Overview: Mitsubishi Chemical is a significant player in the global pharmaceutical industry, providing a wide range of pharmaceutical intermediates including 2-Amino-5-chloropyridine. The company focuses on sustainable manufacturing practices and state-of-the-art production facilities.

• Key Products: Pharmaceutical intermediates, custom synthesis, and high-purity APIs for various therapeutic areas.

6. Syngene International

• Location: Bangalore, India

• Overview: Syngene is a premier contract research and manufacturing organization (CRMO) offering high-quality custom synthesis services. They are a significant player in the production of pharmaceutical intermediates and act as a reliable partner for global pharmaceutical companies.

• Key Products: Custom synthesis of pharmaceutical intermediates and APIs, process development.

7. Cambrex Corporation

• Location: East Rutherford, New Jersey, USA

• Overview: Cambrex specializes in the development and manufacture of small molecule APIs and intermediates. They work with pharmaceutical companies to provide high-quality custom synthesis services, including 2-Amino-5-chloropyridine.

• Key Products: Small molecule APIs, custom synthesis, and process development services.

8. Sandoz (Novartis Division)

• Location: Holzkirchen, Germany

• Overview: Sandoz, a division of Novartis, is a leader in the generics market and manufactures a wide range of pharmaceutical intermediates, including 2-Amino-5-chloropyridine. The company is known for its high-quality generics and biosimilars.

• Key Products: Intermediates for generics, APIs, biosimilars, and injectable formulations.

9. Cipla

• Location: Mumbai, India

• Overview: Cipla is a leading global pharmaceutical company, known for its commitment to producing affordable medicines. The company manufactures a range of pharmaceutical intermediates, including those for complex generics and active ingredients.

• Key Products: Generics and APIs for various therapeutic areas, including respiratory, oncology, and HIV treatments.

10. Mylan Pharmaceuticals (now part of Viatris)

• Location: Canonsburg, Pennsylvania, USA

• Overview: Mylan, now part of Viatris, is a major player in the generics industry and manufactures pharmaceutical intermediates like 2-Amino-5-chloropyridine. The company’s global presence supports markets in North America, Europe, and Asia.

• Key Products: Generic APIs, pharmaceutical intermediates, and custom synthesis services.

Trends in the Pharmaceutical Intermediates Market

Growing Demand for Generics and Biosimilars:

The rise of generics and biosimilars is significantly driving the demand for pharmaceutical intermediates like 2-Amino-5-chloropyridine. As healthcare costs continue to climb, these cost-effective alternatives are increasingly popular in both developed and emerging markets.

Advancements in Process Chemistry and Manufacturing:

The pharmaceutical industry is adopting more advanced manufacturing techniques to increase efficiency and sustainability. Innovations like continuous flow chemistry and automation are improving production processes for intermediates such as 2-Amino-5-chloropyridine.

Regulatory Challenges:

With stringent global regulatory standards, pharmaceutical companies must ensure that intermediates meet all compliance requirements. Companies manufacturing 2-Amino-5-chloropyridine are investing in advanced technologies to meet these standards and avoid costly product recalls.

Sustainability Initiatives:

Environmental concerns are driving companies to adopt more sustainable practices in the production of pharmaceutical intermediates. Green chemistry, waste reduction, and energy-efficient manufacturing are becoming increasingly important in the pharmaceutical sector.

Conclusion

2-Amino-5-chloropyridine (CAS No. 4271-96-9) is an essential pharmaceutical intermediate that plays a crucial role in the synthesis of a wide range of therapeutic drugs. From generics to complex biologics, its role in drug manufacturing is indispensable.

The companies listed above—Lonza, BASF, Eastfine, Mitsubishi Chemical, and others—are leading the way in producing high-quality 2-Amino-5-chloropyridine, ensuring that the pharmaceutical industry can meet global demand for safe and effective medications. With the growing emphasis on sustainability, regulatory compliance, and innovation, the pharmaceutical intermediates market is set to continue evolving, and companies that can navigate these trends will be well-positioned for success.