Top 10 Manufacturers of Pharmaceutical Intermediate CAS No. 3721-95-7 in 2025

Understanding CAS No. 3721-95-7 – A Strategic Intermediate for Antifungal and Antiprotozoal Drugs

CAS No. 3721-95-7, known as 2-Chloro-4-nitrobenzoic acid, is a critical halogenated aromatic intermediate used extensively in the synthesis of antifungal, antiprotozoal, and antibacterial active pharmaceutical ingredients (APIs). It plays a central role in constructing heterocyclic scaffolds and nitro-substituted compounds with high biological activity.

Its dual electron-withdrawing groups (chloro and nitro) enhance its chemical reactivity, making it valuable in pharmaceutical research and large-scale commercial drug manufacturing.

Importance of CAS No. 3721-95-7 in Pharmaceutical Manufacturing

Key Intermediate in Azole and Imidazole Derivatives

Widely used in the synthesis of antifungal drugs, including compounds structurally similar to ketoconazole and metronidazole.

Electron-Deficient Aromatic System

Enables nucleophilic substitution reactions crucial for downstream pharmaceutical development.

High Stability and Reactivity

Ideal for storage, long-distance transportation, and scalable industrial processes.

Versatile for API Side Chains and Core Structures

Applicable across antimicrobial, antiprotozoal, and gastrointestinal drug classes.

Subject to Regulatory Oversight

Manufacturing requires strict adherence to impurity control, documentation, and global GMP protocols.

Top 10 Manufacturers of CAS No. 3721-95-7

1. BASF

• Location: Ludwigshafen, Germany

• Overview: Global chemical producer with advanced capabilities in aromatic and nitro compound synthesis.

• Specialty: Scalable production with full REACH and ICH Q7 compliance.

2. Jubilant Ingrevia

• Location: Uttar Pradesh, India

• Overview: Major supplier of halogenated benzoic acids and nitroaromatics for pharmaceutical use.

• Specialty: High batch consistency and backward-integrated raw materials.

3. Eastfine

• Location: Changzhou City, Jiangsu Province, China

• Overview: A leading supplier of CAS 3721-95-7 for antiprotozoal and antifungal drug production.

• Specialty: Cost-effective, export-ready, and supported by full documentation packages.

4. Aarti Pharmalabs

• Location: Maharashtra, India

• Overview: Experienced in the manufacture of nitro- and chloro-substituted aromatic intermediates.

• Specialty: Integrated environmental controls and high-purity outputs.

5. WeylChem International

• Location: Frankfurt, Germany

• Overview: Offers custom synthesis of chlorinated and nitro-substituted aromatic intermediates.

• Specialty: EU-GMP operations and robust process chemistry development.

6. Farmhispania Group

• Location: Barcelona, Spain

• Overview: European CDMO with a focus on antimicrobial intermediate production.

• Specialty: Flexible scale operations and regulatory inspection readiness.

7. Neuland Laboratories

• Location: Hyderabad, India

• Overview: Supplies regulatory-grade intermediates for antifungal and gastrointestinal APIs.

• Specialty: Emphasis on compliance, traceability, and supply chain transparency.

8. Cambridge Major Laboratories (now part of Curia Global)

• Location: Albany, New York, USA

• Overview: Specializes in development-stage intermediates and clinical trial materials.

• Specialty: Small- to mid-scale cGMP synthesis with full analytical support.

9. Delmar Chemicals

• Location: Montreal, Canada

• Overview: Custom manufacturer of specialty aromatics and nitrobenzoic acid derivatives.

• Specialty: Strong regulatory support and impurity control systems.

10. Enamine Ltd.

• Location: Kyiv, Ukraine

• Overview: Leading European supplier of pharmaceutical building blocks and research intermediates.

• Specialty: Advanced nitroaromatic synthesis and rapid lead-time on custom orders.

Trends in the Pharmaceutical Intermediates Market

Steady Demand for Antifungals and Antiprotozoals

The rise of resistant fungal strains has increased the need for core intermediates like CAS 3721-95-7.

Focus on Halogenated Aromatics

As drug structures become more complex, chlorinated benzoic acids are gaining strategic importance.

Globalization of CDMO Networks

Regulatory bodies favor suppliers with well-documented compliance across continents.

Cleaner Nitration and Chlorination Processes

Sustainability mandates are pushing suppliers to adopt greener nitration technologies.

Increased Vetting of Supply Chains

API makers are securing contracts with high-integrity intermediate manufacturers for long-term reliability.

Conclusion

CAS No. 3721-95-7—2-Chloro-4-nitrobenzoic acid—is a cornerstone intermediate in the development of antifungal, antimicrobial, and antiprotozoal drugs. With global health systems placing a growing emphasis on infectious disease control, the demand for this compound is expected to remain strong.

Suppliers like Eastfine, BASF, Jubilant, and Aarti Pharmalabs continue to lead the industry by offering regulatory-grade material with consistent performance, global documentation, and scalable production.