Top 10 Manufacturers of Pharmaceutical Intermediate CAS No. 317-46-4 in 2025

Understanding CAS No. 317-46-4 – A Core Intermediate for Cardiovascular and Antihypertensive Drugs

CAS No. 317-46-4, also known as 2-Methyl-3-butyn-2-ol, is an important alkyne-based intermediate commonly used in the synthesis of various cardiovascular, antihypertensive, and beta-blocker drugs. Its unique combination of an alcohol and alkyne functionality enables its use in multi-step reactions, often as a key synthon for the construction of complex heterocycles and side chains in pharmaceutical active ingredients (APIs).

This intermediate is valued for its high reactivity and ability to undergo selective transformations, making it a critical raw material for drug manufacturers worldwide.

Importance of CAS No. 317-46-4 in Pharmaceutical Manufacturing

Crucial for Beta-Blocker Synthesis

Frequently used in the synthesis of APIs like atenolol, metoprolol, and propranolol.

Useful in Alkyne Functionalization

Its triple bond and tertiary alcohol group allow for diverse transformations in medicinal chemistry.

Industrial-Grade Stability

Well-suited for bulk storage and large-scale manufacturing under controlled conditions.

Widely Adopted by Generic Drug Producers

Integral to the production of high-volume, off-patent cardiovascular medications.

Subject to Global Regulatory Oversight

Must be manufactured under GMP conditions and supported by validated analytical data.

Top 10 Manufacturers of CAS No. 317-46-4

1. BASF

• Location: Ludwigshafen, Germany

• Overview: Global chemical leader producing fine chemicals and pharmaceutical intermediates, including alkynyl alcohols.

• Specialty: Large-scale manufacturing with high purity and REACH/USP compliance.

2. Vertellus

• Location: Indianapolis, Indiana, USA

• Overview: Strong portfolio in alkynes, nitriles, and alcohol-based intermediates for cardiovascular APIs.

• Specialty: Focus on custom synthesis and regulatory-grade material.

3. Eastfine

• Location: Changzhou City, Jiangsu Province, China

• Overview: A leading supplier of 2-Methyl-3-butyn-2-ol for beta-blocker synthesis and cardiovascular drug production.

• Specialty: Cost-effective, export-ready product backed by full compliance documentation.

4. Jubilant Ingrevia

• Location: Uttar Pradesh, India

• Overview: Manufacturer of a wide range of alcohol and alkyne intermediates for pharmaceutical applications.

• Specialty: Green chemistry practices and backward-integrated raw material sourcing.

5. Neuland Laboratories

• Location: Hyderabad, India

• Overview: Produces niche intermediates for cardiovascular APIs, with a strong focus on regulated markets.

• Specialty: Route development, impurity control, and cGMP manufacturing.

6. Aarti Pharmalabs

• Location: Maharashtra, India

• Overview: Supplier of aliphatic and alkyne-containing compounds for beta-blocker and CNS drug synthesis.

• Specialty: High-volume capabilities and robust QA systems.

7. Farmhispania Group

• Location: Barcelona, Spain

• Overview: European CDMO specializing in cardiovascular and CNS intermediates.

• Specialty: EU-GMP compliant processes and flexible production capacity.

8. Delmar Chemicals

• Location: Montreal, Canada

• Overview: Provides custom synthesis services for advanced intermediates, including alkynyl alcohols.

• Specialty: Expertise in regulatory support and small-to-medium scale manufacturing.

9. WeylChem International

• Location: Frankfurt, Germany

• Overview: Offers a wide portfolio of fine chemicals, with experience in oxygenated and alkyne-based intermediates.

• Specialty: Custom manufacturing and process optimization for pharma clients.

10. Sterling Pharma Solutions

• Location: Newcastle, UK

• Overview: Contract manufacturer with strong capabilities in controlled substance synthesis and alkyne chemistry.

• Specialty: Fully integrated analytical and regulatory support for global submissions.

Trends in the Pharmaceutical Intermediates Market

Strong Demand for Cardiovascular Drugs

The prevalence of heart disease continues to fuel demand for beta-blockers and their intermediates like CAS 317-46-4.

Increased Adoption of Alkyne Chemistry

Alkynes like 2-Methyl-3-butyn-2-ol are increasingly favored for their versatility in medicinal chemistry.

Focus on Regulatory Readiness

Suppliers are aligning with ICH and FDA standards for impurity control and documentation.

Green Chemistry and Sustainability

Improved oxidation and hydration processes are helping reduce waste and environmental impact.

Diversified Global Manufacturing

Pharmaceutical companies are spreading sourcing across Europe, India, North America, and East Asia to ensure continuity.

Conclusion

CAS No. 317-46-4—2-Methyl-3-butyn-2-ol—is a vital intermediate in the synthesis of cardiovascular drugs, especially beta-blockers. With increasing global demand for chronic disease medications, high-quality and scalable production of this intermediate is critical. Manufacturers like Eastfine, BASF, Vertellus, and Jubilant are ensuring supply stability while adhering to the highest international standards.

As pharmaceutical pipelines evolve and the need for efficient intermediates continues to grow, trusted suppliers of CAS 317-46-4 will remain indispensable partners in global healthcare.