Views: 0 Author: Site Editor Publish Time: 2025-07-30 Origin: Site
CAS No. 179232-29-2, chemically known as Methyl N-[(1S)-1-{[(2S,3S)-2-hydroxy-3-[(2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoyl]amino}-4-phenylbutyl]carbamoyl}-2-phenylethyl]carbamate, is a vital intermediate used in the synthesis of Atazanavir sulfate, a protease inhibitor employed in the treatment of HIV infection.
This intermediate contains multiple stereocenters and functional groups, making its synthesis highly specialized. Its quality and stereochemical integrity directly affect the efficacy and safety of the final Atazanavir API.
Forms the structural backbone of Atazanavir, critical for its antiviral activity.
Stereochemistry must be tightly controlled to ensure biological activity and reduce side effects.
Supports production for both proprietary formulations and WHO-approved generics.
Must meet GMP, ICH Q7, and regional regulatory standards for impurity profiling and stability.
Used in medications provided through international HIV treatment initiatives.
Location: Barcelona, Spain
Overview: A top-tier European producer of HIV drug intermediates, including advanced chiral building blocks.
Specialty: Synthesis of complex antiviral intermediates under EU-GMP.
Location: Albany, New York, USA
Overview: Offers advanced CDMO services for antiviral intermediates, with full regulatory and analytical support.
Specialty: Strong in route optimization and late-phase manufacturing.
Location: Changzhou City, Jiangsu Province, China
Overview: Eastfine supplies high-purity CAS 179232-29-2 globally, providing strong technical documentation and quality control.
Specialty: Affordable, GMP-compliant production for antiretroviral drugs.
Location: Hyderabad, India
Overview: A trusted supplier of HIV protease inhibitor intermediates, offering full lifecycle CDMO services.
Specialty: Deep expertise in stereoselective synthesis and scale-up.
Location: Milan, Italy
Overview: Manufactures high-potency pharmaceutical intermediates and APIs under FDA and EMA oversight.
Specialty: Chiral chemistry and regulatory excellence.
Location: Maharashtra, India
Overview: Manufacturer of antiretroviral intermediates for generic drug production, supplying regulated markets.
Specialty: Consistent, large-scale production with technical support.
Location: Mumbai, India
Overview: Global pharmaceutical company producing TLD-based HIV treatments and key intermediates.
Specialty: WHO-prequalified supply chain with backward integration.
Location: Northumberland, UK
Overview: CDMO with expertise in custom manufacturing of complex antiviral intermediates.
Specialty: Containment manufacturing and global regulatory compliance.
Location: Montreal, Canada
Overview: Specializes in GMP manufacturing of pharmaceutical intermediates for the North American market.
Specialty: Flexible batch sizes and full regulatory documentation.
Location: Hyderabad, India
Overview: Manufacturer of APIs and intermediates for antiretroviral therapy, with multiple USFDA-inspected sites.
Specialty: Quality-driven production and contract development services.
As HIV/AIDS treatment becomes more accessible globally, the need for intermediates like CAS 179232-29-2 continues to grow.
Manufacturers are investing in technologies that enhance stereoselective synthesis and reduce epimer formation.
Companies are diversifying suppliers across India, Europe, and China to ensure consistent supply and reduce geopolitical risks.
Process intensification and greener solvents are being used to make synthesis more eco-friendly and cost-effective.
Specialized outsourcing partners are increasingly being used for complex intermediate production to save time and investment.
CAS No. 179232-29-2 is an advanced chiral intermediate vital to the synthesis of Atazanavir, a frontline HIV protease inhibitor. With trusted global manufacturers such as Eastfine, Farmhispania, Sai Life Sciences, and Curia, the global supply chain remains strong, compliant, and scalable to support both generic and branded HIV treatment programs.
As HIV therapy continues to evolve and expand globally, high-quality manufacturers of intermediates like CAS 179232-29-2 play a crucial role in making life-saving treatments accessible and affordable.
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