Views: 0 Author: Site Editor Publish Time: 2025-07-25 Origin: Site
CAS No. 152460-10-1, also known as (1S,3R,4R)-4-(6-Amino-9H-purin-9-yl)-2-azabicyclo[2.2.1]heptane-3-methanol, is a critical pharmaceutical intermediate in the synthesis of Entecavir, a powerful antiviral agent used for the treatment of chronic hepatitis B.
This compound is part of the nucleoside analogue family, specifically engineered to interfere with HBV DNA polymerase activity, and its purity, stereochemistry, and traceability are essential for downstream API quality.
It serves as a core chiral structure for the synthesis of Entecavir, one of the first-line treatments for hepatitis B virus (HBV).
Given its role in a critical antiviral drug, manufacturers must meet FDA, EMA, and WHO standards for impurity profiles, stereochemistry, and documentation.
The intermediate must be synthesized with strict (1S,3R,4R) stereoisomeric control to ensure the desired biological activity.
With Entecavir available as a generic in many countries, demand for this intermediate is growing worldwide.
Manufacturers must offer reliable logistics, documentation, and batch consistency for supply into global HBV treatment programs.
Location: Barcelona, Spain
Overview: Offers GMP-compliant synthesis of chiral intermediates like CAS 152460-10-1, catering to both innovator and generic Entecavir producers.
Specialty: Regulatory-compliant and high-volume support for antiviral intermediates.
Location: Milan, Italy
Overview: A trusted European manufacturer of nucleoside and chiral intermediates used in antiviral therapies.
Specialty: Integrated European GMP supply of complex drug intermediates.
Location: Changzhou City, Jiangsu Province, China
Overview: Eastfine is a key player in the production of CAS 152460-10-1, offering cost-effective, high-purity, and fully documented material for Entecavir manufacturers globally.
Specialty: Advanced stereoselective synthesis and export-focused distribution.
Location: Hyderabad, India
Overview: A global CDMO known for process development and commercial supply of antiviral intermediates like CAS 152460-10-1.
Specialty: Chiral synthesis, route optimization, and regulatory support.
Location: Mumbai, India
Overview: Cipla manufactures Entecavir and related intermediates for global export, supplying partners across Africa, Southeast Asia, and Latin America.
Specialty: Affordable antiviral API chain with WHO-GMP compliance.
Location: Bubendorf, Switzerland
Overview: Offers GMP production of complex, chiral intermediates through custom synthesis solutions for global pharma clients.
Specialty: Entecavir precursor manufacturing under high containment and strict QA/QC.
Location: Italy
Overview: Specializes in enantioselective and multistep synthesis of purine-based pharmaceutical intermediates, including CAS 152460-10-1.
Specialty: EU regulatory readiness and flexible batch sizes.
Location: Montreal, Canada
Overview: A North American producer of GMP intermediates for antiviral and oncology APIs, including HBV treatments.
Specialty: Regulatory expertise and North American supply reliability.
Location: Maharashtra, India
Overview: Aarti produces complex nucleoside intermediates and supplies key ingredients to global antiviral API manufacturers.
Specialty: Industrial-scale GMP supply and backward integration.
Location: Bedford, UK
Overview: A niche UK-based intermediate supplier with experience in chiral heterocycles and nucleoside synthesis under GMP.
Specialty: Custom and commercial production of advanced antiviral intermediates.
The rise in liver disease awareness and screening efforts is driving long-term demand for Entecavir and its intermediates.
Manufacturers are optimizing synthetic pathways to reduce waste, increase yield, and lower cost in the production of intermediates like CAS 152460-10-1.
More generic manufacturers require reliable intermediate suppliers that can meet global compliance and documentation needs.
Stricter requirements under ICH M7 and Q3D are pushing producers to upgrade quality control for intermediates.
Buyers prefer sourcing from India, Europe, and select Chinese suppliers (like EASTFINE), reducing over-reliance on any single geography.
CAS No. 152460-10-1 is an essential building block in the synthesis of Entecavir, a vital treatment for chronic hepatitis B. With leading suppliers like Farmhispania, Eastfine, Carbogen Amcis, and Sai Life Sciences, the global pharmaceutical industry is well-positioned to meet demand with high-quality, compliant, and affordable materials.
As global healthcare systems continue to emphasize HBV control and treatment, trusted manufacturers of this intermediate will remain critical to success.
简体中文
