Views: 0 Author: Site Editor Publish Time: 2025-07-02 Origin: Site
Methyl 2-chloroacetoacetate (CAS No. 1191-95-3) is an essential pharmaceutical intermediate used in the synthesis of a variety of Active Pharmaceutical Ingredients (APIs). This compound, characterized by its chloroacetate and ester group, plays a key role in producing drugs with applications in treating inflammation, infections, and even cancer.
Methyl 2-chloroacetoacetate is typically involved in the production of pharmaceutical agents that require precise chemical reactions. Its reactivity and ability to form complex compounds make it a versatile intermediate in pharmaceutical manufacturing. As with all intermediates, the quality and consistency of Methyl 2-chloroacetoacetate are crucial in ensuring the overall safety and efficacy of the drugs that depend on it.
Methyl 2-chloroacetoacetate serves as a building block in the synthesis of a variety of APIs. It is particularly valuable in the production of anti-inflammatory drugs, antimicrobials, and anticancer agents.
The use of Methyl 2-chloroacetoacetate allows pharmaceutical manufacturers to optimize the production process, reducing complexities and improving cost-efficiency. The availability of high-quality intermediates ensures that drugs can be manufactured at scale, making them more accessible to patients.
Since Methyl 2-chloroacetoacetate is used in the synthesis of pharmaceutical drugs, it must meet rigorous global standards. Regulatory bodies such as the FDA, EMA, and others require that it be produced following Good Manufacturing Practices (GMP) to ensure its safety and quality in pharmaceutical applications.
The ability to produce Methyl 2-chloroacetoacetate on a large scale while maintaining quality ensures that the pharmaceutical industry can meet global demand for various drug products.
Location: Basel, Switzerland
Overview: Lonza is a global leader in the production of pharmaceutical intermediates, including Methyl 2-chloroacetoacetate. The company offers a wide range of services from early-stage development to large-scale commercial production.
Key Products: Biopharmaceutical manufacturing, APIs for oncology, immunology, and other therapeutic areas.
Location: Ludwigshafen, Germany
Overview: BASF is one of the largest chemical companies worldwide, providing high-quality pharmaceutical intermediates like Methyl 2-chloroacetoacetate. Their chemical expertise ensures that all their products meet stringent regulatory requirements.
Key Products: Pharmaceutical intermediates, custom synthesis for generics, and specialty chemicals.
Location: Changzhou City, Jiangsu Province, China
Overview: Eastfine is a well-known Chinese manufacturer of pharmaceutical intermediates, including Methyl 2-chloroacetoacetate. The company specializes in cost-effective, high-quality production, adhering to international regulatory standards.
Key Products: Intermediates for generics and branded drugs, fine chemicals for industrial applications.
Location: Essen, Germany
Overview: Evonik specializes in high-performance materials and chemicals, including intermediates like Methyl 2-chloroacetoacetate. They have a strong focus on sustainability and innovation in the pharmaceutical manufacturing space.
Key Products: Custom synthesis services, intermediates for pharmaceutical applications.
Location: Tokyo, Japan
Overview: Mitsubishi Chemical is a leader in the chemical and pharmaceutical sectors, producing intermediates like Methyl 2-chloroacetoacetate. Their expertise in high-quality manufacturing ensures reliable and efficient production for pharmaceutical needs.
Key Products: High-purity APIs and intermediates for various therapeutic applications.
Location: Bangalore, India
Overview: Syngene is a leading contract research and manufacturing organization (CRMO) specializing in custom synthesis, including Methyl 2-chloroacetoacetate. They support clients across the entire drug development lifecycle.
Key Products: Custom synthesis of pharmaceutical intermediates and APIs.
Location: East Rutherford, New Jersey, USA
Overview: Cambrex provides manufacturing services, including the production of Methyl 2-chloroacetoacetate for pharmaceutical applications. The company is known for its commitment to high-quality production and regulatory compliance.
Key Products: Small molecule APIs, intermediates, and custom synthesis.
Location: Holzkirchen, Germany
Overview: Sandoz, a division of Novartis, is a global leader in generics. They manufacture pharmaceutical intermediates such as Methyl 2-chloroacetoacetate, supporting a broad range of therapeutic areas.
Key Products: Intermediates for generics, biosimilars, and injectables.
Location: Shanghai, China
Overview: Chempacific focuses on the custom synthesis of pharmaceutical intermediates, including Methyl 2-chloroacetoacetate. They specialize in small to mid-scale production, ensuring flexibility and quality in manufacturing.
Key Products: Custom chemical synthesis, pharmaceutical intermediates for various applications.
Location: Canonsburg, Pennsylvania, USA
Overview: Mylan, now part of Viatris, is a significant player in the global generics market. The company produces pharmaceutical intermediates such as Methyl 2-chloroacetoacetate to support a wide range of therapeutic needs.
Key Products: Generic APIs, intermediates for cardiovascular, oncology, and other therapeutic areas.
As healthcare costs rise globally, the demand for generic drugs continues to increase, which drives the need for intermediates like Methyl 2-chloroacetoacetate. These cost-effective alternatives play a crucial role in making essential medicines more affordable.
The pharmaceutical industry is focusing on environmentally sustainable manufacturing practices, including the use of green chemistry in the production of intermediates like Methyl 2-chloroacetoacetate. This approach helps reduce waste and energy consumption.
Regulatory bodies are demanding stricter compliance and transparency in the pharmaceutical manufacturing process. As a result, companies must focus on improving the quality and consistency of intermediates like Methyl 2-chloroacetoacetate to meet global standards.
As personalized medicine grows in importance, the demand for specialized intermediates like Methyl 2-chloroacetoacetate increases. These intermediates are key components in developing drugs tailored to individual patients' needs, particularly in areas like cancer treatment.
Methyl 2-chloroacetoacetate (CAS No. 1191-95-3) is a crucial intermediate used in the synthesis of various APIs. It plays a key role in the production of drugs for a wide range of therapeutic areas, including anti-inflammatory, antimicrobial, and anticancer treatments.
Leading manufacturers like Lonza, BASF, Eastfine, Evonik, and others are at the forefront of ensuring the availability of high-quality Methyl 2-chloroacetoacetate to meet the growing demand in the pharmaceutical industry. With increasing focus on sustainability, innovation, and regulatory compliance, the pharmaceutical intermediates market is poised for continued growth in the coming years.
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