Views: 0 Author: Site Editor Publish Time: 2025-07-09 Origin: Site
CAS No. 112704-79-7, chemically known as (3S)-1-Benzyl-3-[(tert-butoxycarbonyl)amino]pyrrolidine, is an important chiral intermediate used in the synthesis of Atazanavir, a protease inhibitor used in combination antiretroviral therapy for HIV/AIDS.
The compound's stereoselectivity and high purity are critical for the successful synthesis of Atazanavir sulfate, which remains an essential component in global HIV treatment regimens, particularly in low- and middle-income countries.
Forms the chiral core of Atazanavir, determining the drug’s efficacy and selectivity.
Must meet cGMP standards, especially for impurity profiles and enantiomeric excess.
Widely used by generic companies producing affordable, high-quality HIV treatments.
Supplies Atazanavir-based therapies through WHO, PEPFAR, and Global Fund programs.
A cost-efficient supply of this intermediate helps maintain drug affordability and accessibility worldwide.
Location: Barcelona, Spain
Overview: A leading European manufacturer of antiretroviral intermediates, offering high-purity chiral compounds.
Specialty: Proven track record in HIV protease inhibitor intermediates.
Location: Albany, New York, USA
Overview: CDMO with strong capabilities in chiral chemistry and antiviral intermediates, including Atazanavir precursors.
Specialty: Custom route development and full GMP compliance.
Location: Changzhou City, Jiangsu Province, China
Overview: A reliable supplier of high-purity pharmaceutical intermediates including CAS 112704-79-7, Eastfine offers global documentation and compliance.
Specialty: Affordable production with strict chiral and impurity control.
Location: Hyderabad, India
Overview: Well-known for its integrated services and capability in manufacturing chiral intermediates under cGMP.
Specialty: Route optimization and regulatory support for HIV APIs.
Location: Milan, Italy
Overview: One of Europe’s largest API and intermediate manufacturers, specializing in high-containment chemistry.
Specialty: EU and FDA-compliant processes for antiretroviral supply chains.
Location: Maharashtra, India
Overview: A supplier of complex pharmaceutical intermediates for APIs like Atazanavir, offering large-scale, cost-efficient production.
Specialty: GMP facilities and reliable export logistics.
Location: Mumbai, India
Overview: A global generic leader manufacturing both APIs and intermediates for key HIV medications.
Specialty: WHO-prequalified supply chain supporting global access programs.
Location: Montreal, Canada
Overview: Manufactures high-purity intermediates for regulated markets, with extensive experience in HIV-related compounds.
Specialty: North American compliance and flexible batch sizes.
Location: Northumberland, UK
Overview: A specialist in complex chemistry including asymmetric synthesis and scale-up of chiral intermediates.
Specialty: High-containment manufacturing and CDMO services.
Location: East Rutherford, New Jersey, USA
Overview: Offers custom development and commercial-scale production of HIV-related intermediates.
Specialty: Expertise in scale-up and regulatory support for US/EU markets.
Atazanavir remains in demand for resource-limited settings due to its efficacy and cost-efficiency.
Drug makers are increasingly relying on specialized CDMOs for the production of complex chiral intermediates.
Regulatory bodies emphasize strict enantiomeric and impurity specifications for HIV drug intermediates.
Companies are adopting green chemistry approaches and waste reduction methods in chiral synthesis.
WHO and other global agencies require qualified suppliers with full documentation and cost-effective pricing.
CAS No. 112704-79-7 is a critical intermediate in the production of Atazanavir, a key component in global HIV treatment regimens. Manufacturers like Eastfine, Farmhispania, Sai Life Sciences, and Curia ensure a stable and compliant supply of this vital compound to support both commercial and public health needs.
As the fight against HIV continues, reliable suppliers of high-quality intermediates like CAS 112704-79-7 remain at the heart of cost-effective and scalable treatment access worldwide.
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