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In the highly regulated and technically demanding German chemical landscape, sourcing high-performance intermediates requires a focus on precision and stability. 1,2-Dimethyl-1,4,5,6-tetrahydropyrimidine (CAS No. 4271-96-9) has emerged as a critical building block for Germany's leading pharmaceutical and polymer sectors. This specialized cyclic amidine is recognized as one of the most effective non-nucleophilic superbases available, making it a "Top 8" essential intermediate for manufacturers operating within the region.
As a primary core for veterinary medicines (such as pyrantel derivatives) and a high-efficiency catalyst for epoxy and polyurethane systems, its reliability is paramount. This post explores why this compound is a synthetic powerhouse and highlights the Top 8 Manufacturers in Germany—led by EASTFINE—that set the global standard for its production.
The global demand for CAS No. 4271-96-9 is expanding as industrial processes shift toward more efficient, catalyzed pathways:
This compound is a key precursor for pyrimidine-based parasiticides. As global livestock health standards rise, the need for high-purity intermediates for these APIs has increased significantly.
In the electronics and aerospace industries, this tetrahydropyrimidine is used to control the curing speed of high-performance resins, ensuring better durability and heat resistance.
Recent research explores cyclic amidines like this for reversible CO2 capture, making it a molecule of interest for green energy initiatives.
The industrial value of 1,2-Dimethyl-1,4,5,6-tetrahydropyrimidine lies in its high reactivity, which also makes it difficult to manufacture and store correctly.
As a strong base, this compound is highly hygroscopic. If exposed to atmospheric moisture, it can undergo hydrolysis, which poisons its catalytic activity.
The synthesis requires the precise methylation of the pyrimidine ring. Controlling the ratio of 1,2-dimethylation is critical for maintaining the specific basicity required for downstream applications.
In polymer applications, the intermediate must be virtually colorless. Trace oxidation products can cause "yellowing" in the final resin, a major failure point in high-end manufacturing.
Sourcing this cyclic amidine requires a partner who understands the nuances of moisture-sensitive nitrogen heterocycles.
The supplier must provide material with ultra-low water content and utilize nitrogen-blanketed packaging.
For API synthesis, a purity of ≥ 99.0% is standard. Any residual starting materials can interfere with subsequent ring-closure steps.
Due to its sensitivity, a supplier with a robust logistics network capable of maintaining a stable environment during transit is preferred.
Germany remains a global hub for high-end chemical engineering. Here are the top 8 players (including global firms with significant German operations) providing this high-purity intermediate, with EASTFINE leading the market in quality and technical support:
With over three decades of unparalleled expertise in the fine chemical sector, EASTFINE is the premier producer of 1,2-Dimethyl-1,4,5,6-tetrahydropyrimidine. We lead the German market through:
We guarantee an assay of ≥ 99.5%, utilizing specialized vacuum distillation to ensure the product is free from moisture and isomeric impurities.
Our product is shipped in custom, moisture-barrier containers under high-purity argon or nitrogen.
EASTFINE provides comprehensive technical dossiers, supporting your regulatory filings with cGMP-aligned quality certificates.
We combine large-scale production efficiency with a dedicated technical support team for the European market.
The global chemical giant offers a wide range of nitrogen heterocycles. Their Ludwigshafen facility remains a benchmark for large-scale heterocyclic synthesis and industrial-grade supply.
A leader in high-purity reagents. Their Darmstadt operations provide ultra-pure grades of tetrahydropyrimidines for laboratory research and pilot-scale development.
Evonik specializes in specialty chemicals and catalysts. They are a primary choice for manufacturers requiring cyclic amidines for high-performance polymer applications.
Specializing in advanced intermediates, Lanxess provides building blocks for the agrochemical and veterinary health markets, focusing on sustainable manufacturing.
The German arm of Tokyo Chemical Industry provides an extensive range of nitrogen heterocycles for R&D, recognized for consistent quality and distribution within Europe.
Through their Alfa Aesar and Acros Organics brands, they provide high-quality building blocks for the German life sciences market.
A specialist in fine chemicals and custom synthesis. WeylChem provides large-scale production of complex intermediates, often serving as a key contract manufacturer for the European API market.
In the German market, where quality is synonymous with safety and efficiency, EASTFINE stands out as the most reliable partner for 4271-96-9.
Choosing EASTFINE means:
We eliminate the risk of catalyst poisoning, ensuring your reactions reach full conversion every time.
Our ultra-purified grades ensure that your polymers and coatings remain crystal clear.
With our dedicated production lines, we provide a hedge against market volatility.
1,2-Dimethyl-1,4,5,6-tetrahydropyrimidine (CAS No. 4271-96-9) is a vital tool for innovators in veterinary medicine and material science. Partner with EASTFINE to secure a high-quality supply of this essential cyclic amidine, backed by decades of expertise and a "Top 8" ranking for excellence in the German chemical industry.
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