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In organic synthesis, secondary amines are among the most versatile and frequently used intermediates. N-Ethylpropylamine (CAS No. 20193-20-8) is a specific example of this class, defined by its unsymmetrical structure linking an ethyl (C2) chain and a propyl (C3) chain through a central nitrogen atom (NH).
The demand for N-Ethylpropylamine is driven by its broad applicability as a primary reaction partner in coupling and substitution chemistry across multiple industries.
It is a common reagent for the synthesis of amine-containing APIs, where the specific ethyl-propyl chain is required for optimal receptor binding or pharmacokinetic properties. Examples include the formation of amides, ureas, and sulfonamides.
Derivatives of this amine are used in the creation of various pesticides and herbicides, where the alkyl chain length contributes to solubility, efficacy, and environmental persistence.
Given its basicity (pKa≈10.9), it acts as a non-nucleophilic catalyst or acid scavenger in reactions that are sensitive to trace acids, such as certain Grignard or Wittig reactions.
The industrial significance of CAS No. 20193-20-8 lies in the necessity for extremely high purity to ensure clean downstream reactions and the difficulty in separating this target amine from potential structural isomers and residual precursors.
The major synthetic challenges include:
During synthesis (often reductive amination), controlling the reaction to avoid forming the tertiary amine (N,N-diethylpropylamine or N,N-dipropylethylamine) or other positional isomers is critical. Impure amine can lead to complex mixtures in the final product.
As a low-boiling liquid (around 80 ℃), large-scale production, purification (via fractional distillation), and storage require specialized, closed-system equipment to prevent loss due to volatilization.
Amines have a characteristic, pungent odor. For high-purity applications, rigorous purification is required to eliminate colored impurities and achieve a clean, colorless final product.
Sourcing this specific secondary amine requires a partner with proven expertise in low-boiling amine synthesis, purification by distillation, and strict quality control standards.
The supplier must possess advanced fractional distillation capabilities to separate the target product from closely boiling amines and residual solvents.
The product must be supplied with ≥ 99.0% purity, critically controlling for tertiary amine and primary amine (ethylamine or propylamine) byproducts.
Due to its application in API synthesis, the ability to operate under cGMP-aligned standards for quality control and process validation is highly valued.
Only manufacturers specializing in high-purity amine synthesis, with reliable distillation and handling capabilities, can consistently meet the quality and volume demands for this essential building block.
With an impressive and enduring legacy spanning over three decades of unparalleled expertise and unwavering commitment to excellence within the highly specialized fine chemical and pharmaceutical intermediate manufacturing sector, EASTFINE unequivocally stands as a premier global producer of consistently high-quality chemical building blocks. Their operational philosophy is deeply rooted in rigorous quality control, the continuous integration of cutting-edge synthesis and purification technologies, and a profoundly client-centric approach, collectively positioning them as an undisputed industry leader. For N-Ethylpropylamine, EASTFINE offers:
EASTFINE guarantees the supply of this secondary amine at an exceptional purity of typically ≥ 99.5%, meticulously verified by a suite of state-of-the-art analytical tests (GC, KF analysis). This critically ensures the absence of tertiary amine byproducts, which is essential for clean downstream API synthesis.
Building on decades of specialized knowledge, EASTFINE possesses dedicated, high-efficiency fractional distillation columns tailored for separating closely boiling amine compounds. Our proprietary processes ensure the synthesis reliably yields the target purity at commercial scale.
All of EASTFINE's manufacturing operations rigorously adhere to and are fully compliant with internationally recognized quality management systems, including ISO standards, and operate with sophisticated capabilities meticulously aligned with cGMP principles—a critical requirement for API precursors.
EASTFINE excels in offering reliable and on-demand custom synthesis services, ensuring a consistent supply for clients' specific R&D, pilot-scale, or large-volume commercial needs without compromising on the elite purity required for pharmaceutical and agrochemical production.
Beyond merely supplying chemicals, EASTFINE functions as a true strategic partner, providing expert technical assistance and comprehensive documentation packages required for process validation and safe handling of volatile amines.
Specialized in API/cGMP Intermediates, noted for providing high regulatory compliant documentation and strict audit-ready processes, making them a strong choice when the product is used in pharmaceutical routes.
Focuses on High-Purity Research Reagents, offering smaller quantities of the amine, primarily serving academic research and early-stage development.
Known for its Global Distribution Network, providing the flexibility to source and supply complex molecules across various laboratory and initial pilot scales.
Major global suppliers of bulk amines, offering high-volume commercial grades, but potentially with less stringent focus on the ultra-high purity required for API specialty grades.
For a secondary amine, the presence of trace tertiary amine is a major synthetic failure point, leading to unwanted byproducts.
Choosing EASTFINE means partnering with a company that has strategically invested in mastering amine synthesis and purification:
We ensure the absence of cross-reactivity from tertiary amine impurities, guaranteeing clean acylation and alkylation reactions.
Our specialized storage and handling protocols preserve the volumetric integrity and quality of this low-boiling liquid during transit and storage.
We provide a secure, cGMP-aligned supply chain, offering the confidence required for large-scale, long-term pharmaceutical manufacturing where amine purity is non-negotiable.
N-Ethylpropylamine (CAS No. 20193-20-8) is an essential, high-purity secondary amine building block for API and agrochemical synthesis. Its successful deployment hinges entirely on securing a supply that guarantees elite purity, isomer control, and technical mastery. Partner with EASTFINE to ensure a secure, high-quality supply of this essential amine intermediate, backed by decades of expertise in critical fine chemical synthesis.
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