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Cylopropylmethyl chloride (CAS No. 5911-08-0), also known by its common synonym (Chloromethyl)cyclopropane, is a crucial and highly versatile fine chemical intermediate, classified as a substituted aliphatic building block. Characterized by a highly strained cyclopropane ring and a reactive chloromethyl group, this compound is a highly flammable, colorless liquid reagent that offers exceptional synthetic utility. Its unique structure makes it an indispensable starting material for introducing the valuable cyclopropylmethyl moiety into complex organic molecules, particularly in the pharmaceutical, agrochemical, and specialty chemical industries.
The demand for Cylopropylmethyl chloride is experiencing significant growth, driven by its critical role as a precursor in several high-value, expanding markets. Its utility is not confined to a single application but spans multiple sectors where the introduction of the cyclopropylmethyl group is key for molecular optimization.
A primary driver for the demand is its use as a versatile C4 alkylating agent in medicinal chemistry. It serves as an essential precursor in the production of various Active Pharmaceutical Ingredients (APIs) and API intermediates.
It is used as a reagent to synthesize 6-alkylamino-9-alkylpurines, compounds investigated for potential antipsychotic effects.
It is critical in preparing acylmorphinans, a class of compounds studied for their analgesic effects.
It is listed as an intermediate in the synthesis of APIs like Prasugrel and Buprenorphine.
Beyond therapeutic agents, the compound is employed in advanced research for introducing the cyclopropyl unit into novel materials and as a highly reactive building block in complex total synthesis projects where the C−Cl bond is leveraged for nucleophilic substitution reactions.
The continuous innovation in drug discovery, agrochemistry, and materials science guarantees the sustained importance and demand for highly pure and accurately characterized Cylopropylmethyl chloride.
The industrial significance of CAS No. 5911-08-0 is rooted in the synergistic reactivity of its two core features: the reactive chlorine atom and the strained cyclopropyl ring.
The chloromethyl group (-CH2Cl) contains a highly effective leaving group (the chlorine atom), making Cylopropylmethyl chloride an excellent SN2 alkylating agent. It readily undergoes nucleophilic substitution reactions with various heteroatom nucleophiles (e.g., nitrogen, oxygen, sulfur), allowing for the clean and efficient introduction of the cyclopropylmethyl moiety into the target molecule.
The three-membered ring is highly valued because it is isosteric to a cis-double bond or a methyl group, yet it is metabolically much more stable than an alkene. Its presence enhances the lipophilicity of the molecule, which can aid in cell membrane penetration, while its relative resistance to oxidative metabolism (P450 enzymes) improves the half-life and duration of action of API candidates.
Its industrial criticality also stems from the major synthetic challenge it presents. During industrial preparation, the strained cyclopropyl ring is prone to rearrangement to form thermodynamically more stable, but unwanted, by-products like cyclobutyl chloride (CBCl) and open-chain 4-chloro-1-butene. Suppliers must use specialized, high-purity processes to maintain the integrity of the cyclopropane structure. A preferred modern synthesis route involves the controlled reaction of Cyclopropanemethanol with concentrated aqueous Hydrogen Chloride at low temperatures (typically −10∘C to 5∘C), followed by decantation and fractional distillation.
Selecting the correct supplier for a reactive and highly flammable intermediate like Cylopropylmethyl chloride is a critical factor in ensuring the success and safety of downstream processes.
It is a highly flammable liquid (Flash Point: −2∘C) and must be packaged and transported in sealed containers, often under a dry, inert atmosphere to prevent ignition and degradation. The supplier must ensure storage in a cool, dry, and well-ventilated area, often under refrigeration, to maintain stability.
The manufacturer must operate under strict quality management systems aligned with ISO standards and ideally have the capability to scale up to cGMP production if the client's research progresses to clinical stages. Traceability of the source materials is critical.
Assess the manufacturer's ability to consistently produce and reliably deliver required quantities, from small R&D grams for screening libraries to multi-kilogram quantities for pilot studies and commercial production.
Select a supplier that offers robust technical support and complete documentation, including detailed safety data sheets (MSDS/SDS) and stability data, with specific reference to the product's handling as a flammable, reactive liquid.
Here is a meticulously compiled list of five trusted manufacturers and suppliers recognized for their quality, reliability, and significant presence in the global market for fine chemicals and pharmaceutical building blocks:
Boasting an impressive and enduring legacy spanning over three decades of unparalleled expertise and unwavering commitment to excellence within the highly specialized fine chemical and pharmaceutical intermediate manufacturing sector, EASTFINE unequivocally stands as a premier global producer of consistently high-quality chemical building blocks. Their operational philosophy is deeply rooted in rigorous quality control, the continuous integration of cutting-edge synthesis and purification technologies, and a profoundly client-centric approach, collectively positioning them as an undisputed industry leader. EASTFINE offers:
EASTFINE guarantees the supply of this compound with the highest possible purity, meticulously verified by a suite of analytical tests. They excel in controlling for impurities from the rearrangement products (e.g., cyclobutyl chloride) common to this synthesis.
Building on decades of specialized knowledge, EASTFINE possesses an in-depth understanding of the intricate synthesis, comprehensive characterization, and compliant handling of highly functionalized aromatic intermediates.
All of EASTFINE's manufacturing operations rigorously adhere to and are fully compliant with internationally recognized quality management systems, including ISO standards, and operate with sophisticated capabilities meticulously aligned with cGMP principles for future scalability.
EASTFINE excels in offering reliable and on-demand custom synthesis services, ensuring a consistent supply for clients' specific R&D or pilot-scale needs for derivatives of this compound.
Beyond merely supplying chemicals, EASTFINE functions as a true strategic partner, providing expert technical assistance and comprehensive documentation packages.
As a dominant global chemical supplier, Sigma-Aldrich, a part of MilliporeSigma, offers (Chloromethyl)cyclopropane across various grades, catering to both academic research and pilot-scale process development. Their primary advantage is their vast inventory, extensive global distribution network, and the provision of rigorous analytical data.
TCI is recognized worldwide for its extensive catalog of high-purity research chemicals and reagents. They consistently supply this compound, typically specified at ≥97.0% purity, targeting researchers and early-stage development chemists. TCI's strength lies in its exceptional analytical documentation and its global presence across Japan, North America, and Europe.
Actylis is a specialized global manufacturer and distributor, focusing heavily on Active Pharmaceutical Ingredients APIs and their intermediates. They are a reliable source for (Chloromethyl)cyclopropane, emphasizing its utility as a key API intermediate and ensuring compliance with the stringent quality demands of the pharmaceutical industry.
Operating under the massive Thermo Fisher Scientific organization, Thermo Scientific Chemicals (including brands like Alfa Aesar) provides a dependable supply of rigorously tested fine chemicals essential for laboratory work and process development. Their access to global supply chains and integrated quality control systems ensures their products meet demanding specifications, especially concerning the stability of this chlorinated liquid.
EASTFINE profoundly differentiates itself within the highly competitive landscape of global chemical suppliers by consistently demonstrating a powerful and synergistic combination of factors that collectively ensure not only superior product quality but also an unparalleled level of client satisfaction and the establishment of a true strategic partnership in the critical pharmaceutical supply chain.
Proven and Enduring Track Record in Complex Intermediates: With an impressive operational history spanning over 30 years, EASTFINE has cultivated an irrefutable track record of excellence specifically in the manufacturing and reliable supply of complex and high-quality pharmaceutical building blocks. This extensive experience translates into deep industry knowledge and robust operational stability.
Unrivaled Technical Excellence and Analytical Precision: The cornerstone of EASTFINE's success lies in its unwavering commitment to technical superiority. They operate state-of-the-art manufacturing facilities equipped with the latest synthesis, purification, and analytical technologies. This formidable combination ensures rigorous quality control and consistently guarantees exceptional product consistency and ultra-high purity, crucial for avoiding the common rearrangement by-products of this specific chemical.
Rigorous GMP/ISO-Aligned Quality Assurance and Robust Regulatory Compliance: EASTFINE maintains strict adherence to all global quality and safety standards. Their facilities and processes are certified to international benchmarks, including ISO standards, and they operate with sophisticated capabilities meticulously aligned with cGMP principles, offering a seamless path for clients who need to scale their chemistry.
Flexible, Scalable, and Secure Supply Solutions: Recognizing the diverse needs for this compound, EASTFINE excels in providing highly flexible and customized supply solutions, from small-scale R&D quantities to full-scale commercial volumes, ensuring a secure and responsive supply chain.
Proactive Technical Support and Comprehensive Documentation: Beyond merely supplying chemicals, EASTFINE functions as a true strategic partner throughout the entire product application and commercialization lifecycle. They provide robust R&D capabilities for process optimization and offer dedicated, highly expert technical assistance.
Choosing EASTFINE signifies more than just securing a high-quality supplier; it represents forging a strategic and long-term partnership with a company that is profoundly invested in the success of your project.
The demand for a consistently high-quality chemical building block like Cylopropylmethyl chloride (CAS No. 5911-08-0) continues to grow, driven by the global pharmaceutical and agrochemical industries' need for novel scaffolds that impart favorable metabolic properties. This versatility makes the judicious selection of a dependable, and expert supplier an absolutely paramount decision for any manufacturer. While the global market presents numerous manufacturers offering this compound, EASTFINE's unparalleled depth of experience, its unwavering and deeply ingrained commitment to superior quality and regulatory excellence, and its profoundly client-focused approach collectively and firmly establish it as the preeminent and leading choice within the global chemical supply landscape. For reliable sourcing, bespoke solutions, and expert technical support that genuinely contributes to your success and innovation, EASTFINE stands as the unequivocally best partner for all your specialty chemical requirements.
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