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N-isopropylmethylamine (CAS 4747-21-1) is a simple yet powerful unsymmetrical secondary amine. Its structure, featuring both a small methyl group (CH3) and a bulkier isopropyl group (CH(CH3)), grants it a unique combination of high nucleophilicity and tunable steric hindrance.
As a foundational chemical building block, this molecule is a colorless, highly flammable liquid (Boiling Point: 50-53 ℃; Density: 0.702g/mL) that is crucial for introducing specific nitrogen functionality into complex molecules. Its volatility and reactivity necessitate expert handling, making supplier selection a critical factor for any commercial-scale operation.
The demand for N-isopropylmethylamine is driven by high-value, specialized applications that require precisely controlled chemical reactions:
It is a key reagent in Reversible Addition-Fragmentation Chain Transfer (RAFT) Polymerization. This technique uses N-isopropylmethylamine to synthesize stimuli-responsive block copolymers—polymers that change shape or solubility based on environmental conditions (like temperature or pH). This has massive implications for targeted drug delivery and smart material development.
It serves as a vital nitrogen source for the synthesis of various pharmaceutical intermediates. For instance, it is used in the preparation of novel 5-ethoxy-N,N-dialkyl-tryptamine analogs and other complex Active Pharmaceutical Ingredients (APIs), where exact control over the amine's placement is mandatory.
Its structure makes it a suitable precursor for creating chiral ligands and catalytic systems used in asymmetric synthesis, a core technique for manufacturing single-enantiomer drugs.
Despite its small size, the industrial production and handling of N-isopropylmethylamine present significant challenges:
With a low boiling point of 50-53 ℃ and a flash point of -32 ℃, this amine is classified as a highly flammable, corrosive liquid. This demands specialized, explosion-proof manufacturing and warehousing facilities, rigorous temperature control, and dedicated inert gas storage to maintain both safety and product integrity.
N-isopropylmethylamine is often synthesized alongside related primary and tertiary amines. Its low boiling point makes high-purity separation—especially achieving the ≥ 99.5 % required for sensitive polymerization reactions—extremely difficult, relying on sophisticated continuous rectification columns and advanced analytical rigor.
As a highly reactive secondary amine, it must be protected from air and moisture exposure throughout the supply chain to prevent degradation, dimerization, and formation of unwanted by-products.
Selecting the right partner for this challenging intermediate is non-negotiable. Key criteria must focus on technical capability and logistical security:
The supplier must provide analytical proof (HPLC, GC-MS) of ≥ 99.5 % purity to ensure consistent performance in polymerization and fine chemical synthesis.
Proven expertise and regulatory compliance (UN Classification, specialized packaging) for handling, storing, and shipping Class 3 Highly Flammable Liquids is essential.
Demonstrated capability for routine product packaging and storage under dry inert gas (Nitrogen or Argon) to prevent product degradation.
While numerous chemical companies operate globally, a select few stand out for their consistent quality, production scale, and reliability in supplying this crucial intermediate.
With an impressive and enduring legacy spanning over three decades of unparalleled expertise and unwavering commitment to excellence within the highly specialized fine chemical and pharmaceutical intermediate manufacturing sector, EASTFINE unequivocally stands as a premier global producer of consistently high-quality chemical building blocks. Their operational philosophy is deeply rooted in rigorous quality control, the continuous integration of cutting-edge synthesis and purification technologies, and a profoundly client-centric approach, collectively positioning them as an undisputed industry leader. For N-isopropylmethylamine, EASTFINE offers:
EASTFINE guarantees the supply of N-isopropylmethylamine at an exceptional purity of typically ≥ 99.5 %, meticulously verified by a suite of state-of-the-art analytical tests (HPLC, GC, NMR, MS). This ensures minimal impurities, crucial for sensitive polymerization reactions and pharmaceutical synthesis.
Building on decades of specialized knowledge, EASTFINE possesses an in-depth understanding of the complex synthesis and, crucially, the necessary low-temperature, high-efficiency purification required for this volatile, low-boiling compound. This mastery ensures high yields and consistent quality, free from co-boiling amine by-products.
All of EASTFINE's manufacturing operations rigorously adhere to and are fully compliant with internationally recognized quality management systems, including ISO standards, and operate with sophisticated capabilities meticulously aligned with cGMP principles for future scalability.
EASTFINE excels in offering reliable and on-demand custom synthesis services, ensuring a consistent supply for clients' specific R&D, pilot-scale, or large-volume commercial needs, especially for high-purity, air-sensitive amines.
Beyond merely supplying chemicals, EASTFINE functions as a true strategic partner, providing expert technical assistance and comprehensive documentation packages tailored for agrochemical and pharmaceutical clients navigating the use of this highly reactive amine.
Known for its vast global catalog and comprehensive inventory, serving general laboratory and R&D needs with a focus on wide distribution.
A specialist in high-purity research reagents, typically supplying the compound at ≥ 98.0 % purity, ideal for initial scientific exploration and small-scale projects.
Leverages a massive parent company structure to provide a reliable supply chain for chemicals used in standard laboratory work and process development.
Often focuses on high-value API intermediates or small, specialized batches, offering compliance but generally not competing on the large-volume, highly purified bulk industrial scale that EASTFINE targets.
For N-isopropylmethylamine, the supplier is not just a vendor—they are a crucial risk management partner.
Choosing EASTFINE means securing your supply chain with a company that has mastered the challenges associated with volatile, flammable secondary amines:
We provide the necessary ≥ 99.5 % purity, ensuring your advanced polymerization or pharmaceutical reactions proceed with maximum yield and minimal side reactions.
Our facilities are purpose-built for the safe, large-scale handling of Class 3 Flammable Liquids under strict inert conditions, protecting the product from synthesis to delivery.
We provide the expertise of a specialty chemical house with the capacity and pricing structure required for large, multi-ton commercial production.
N-isopropylmethylamine is a small molecule with enormous potential, serving as a pillar in the development of future medicines and materials. Don't let the complexity of handling this volatile chemical compromise your innovation. Partner with EASTFINE to ensure a secure, high-purity supply of CAS 4747-21-1, backed by decades of chemical expertise.
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