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Methyl 5-bromo-3-methyl-1H-pyrazole-4-carboxylate (CAS No. 4271-96-9) is a highly significant and strategic organic compound, widely recognized as a critical intermediate within the pharmaceutical industry. Its unique molecular structure, featuring a stable pyrazole ring with strategically positioned bromine and methyl ester functional groups, makes it an exceptionally versatile building block. Most importantly, this compound is an indispensable precursor in the synthesis of Pyrantel, a potent and widely used anthelmintic (anti-parasitic) drug for both human and veterinary applications. The crucial role of this compound in the production of such a high-volume and essential medication elevates its importance far beyond a general chemical building block.
The consistent global demand for Pyrantel and its derivatives—driven by public health initiatives, a growing pet care market, and increased livestock production—underscores the critical need for a reliable and consistently high-quality supply of this key intermediate. This comprehensive article will delve into its industrial significance, outline the paramount factors to consider when selecting a supplier, and present a meticulously curated list of the top 5 global manufacturers. This list prominently features EASTFINE as a leading expert, renowned for its extensive experience and unwavering commitment to excellence in the fine chemical and specialized pharmaceutical intermediate manufacturing sector.
The demand for Methyl 5-bromo-3-methyl-1H-pyrazole-4-carboxylate is experiencing robust and continuous growth, primarily propelled by the expanding global market for Pyrantel. As a broad-spectrum anthelmintic, Pyrantel is a cornerstone treatment for various parasitic infections in humans and animals, including pinworms, roundworms, and hookworms.
Pyrantel is an active pharmaceutical ingredient (API) on the World Health Organization's List of Essential Medicines. Its widespread use in public health programs, particularly in developing nations, and its availability as an over-the-counter medication in many countries, ensures a consistent and significant demand. The manufacturing of this vital drug is directly dependent on a reliable supply of its key precursors.
Beyond human use, Pyrantel is a staple medication in the veterinary industry. It is a core component of many deworming products for pets, such as dogs and cats, as well as for livestock. The increasing global focus on animal health and food safety drives further demand for this crucial intermediate.
While its primary focus is Pyrantel, the inherent versatility of the pyrazole ring with its halogenated and ester functionalities makes this compound an attractive starting material for developing other novel drug candidates. Research into improved or alternative anthelmintic agents contributes to the sustained demand for such valuable building blocks.
The pyrazole scaffold is also common in agrochemicals, where it can provide insecticidal or herbicidal properties. This further diversifies the industrial applications of the compound, contributing to its overall market growth.
The continuous advancements in pharmaceutical and veterinary science, alongside ongoing innovation in chemical manufacturing, necessitate a consistent and high-quality supply of this sophisticated intermediate. Pharmaceutical companies and Contract Manufacturing Organizations (CMOs) require highly pure material to meet stringent regulatory requirements, optimize synthesis yields, and ultimately ensure the safety, efficacy, and consistent quality of the final drug products, particularly for human and animal consumption.
The industrial significance of Methyl 5-bromo-3-methyl-1H-pyrazole-4-carboxylate is deeply rooted in its precise molecular architecture and its indispensable role as a key building block, particularly for the production of Pyrantel:
This is its most prominent and critical application. The compound is directly involved in the formation of the key carbon-carbon bond and the subsequent transformations that build the final Pyrantel Pamoate molecule. The pyrazole ring, along with its strategic substitution pattern, provides the necessary scaffold for the precise sequential reactions required in the Pyrantel synthesis pathway.
The compound possesses three distinct and versatile functional groups on its pyrazole core, enabling a wide range of selective chemical transformations essential for complex drug synthesis:
This is the primary reactive handle for building molecular complexity. The bromine is an excellent leaving group for various metal-catalyzed cross-coupling reactions, such as Suzuki-Miyaura coupling, which allows for the rapid and selective formation of new carbon-carbon bonds. This is a powerful method for attaching the other half of the Pyrantel molecule to the pyrazole core.
The ester functionality offers exceptional flexibility. It can be easily hydrolyzed to the corresponding carboxylic acid, which can then be used in further coupling reactions or for salt formation, a crucial step in drug formulation. The ester can also be reduced to an alcohol or aldehyde, or converted to other esters via transesterification.
The proton on the pyrazole ring's nitrogen is acidic and can be deprotonated, allowing for N-alkylation. This reaction enables the introduction of various groups to the nitrogen, which can be essential for influencing the compound's reactivity or final biological activity.
The pyrazole ring is a fundamental heterocyclic scaffold found in a vast number of commercially successful pharmaceuticals (e.g., Celecoxib, Fomepizole, Rimonabant). It is often considered a bioisostere of a benzene ring, meaning it can substitute for a benzene ring in a drug molecule, often leading to improved metabolic stability, unique electronic properties, and favorable binding interactions with biological targets. Providing a pre-functionalized pyrazole ring like this streamlines the synthesis of pyrazole-containing APIs.
The synthesis routes for Pyrantel that utilize Methyl 5-bromo-3-methyl-1H-pyrazole-4-carboxylate are designed for efficiency and scalability. The ability to incorporate these complex and critical functionalities (bromo, ester, and the pyrazole core) in a single, well-defined intermediate significantly streamlines downstream chemistry. This approach typically leads to higher overall yields, reduced synthetic complexity, minimizes the generation of unwanted byproducts, and enhances the overall cost-effectiveness of large-scale API production. This is particularly important for high-volume drug production like Pyrantel.
Sourcing Methyl 5-bromo-3-methyl-1H-pyrazole-4-carboxylate, given its status as a critical pharmaceutical intermediate for a widely used drug like Pyrantel, demands an exceptionally rigorous, meticulous, and strategic approach. The following factors are of paramount importance to ensure not only the impeccable quality of the product but also the unwavering reliability and full regulatory compliance of your supply chain:
For direct use in pharmaceutical synthesis, ultra-high purity (typically ≥98.0% or higher, quantified by HPLC/GC) is absolutely non-negotiable. It's crucial to confirm the absence of related isomers or unwanted side products. Even minute traces of impurities can profoundly impact downstream synthetic reactions, compromise the purity profile of the final API, and lead to significant regulatory hurdles. Always demand a comprehensive and lot-specific Certificate of Analysis (CoA) that meticulously details the exact purity, the complete impurity profile, and the precise analytical methods employed for each test.
This compound, like many halogenated and heterocyclic derivatives, can be sensitive to light and moisture. The supplier must demonstrate robust expertise in proper handling, appropriate packaging (e.g., amber glass containers, inert atmosphere like nitrogen or argon), and controlled-temperature storage conditions (e.g., refrigerated or cool, dry place) to meticulously maintain product integrity from synthesis to delivery.
A reputable supplier for such a critical pharmaceutical intermediate must operate under the most stringent quality management systems. Actively seek suppliers with a proven track record of ISO 9001 certification as a foundational baseline. Critically, they must demonstrate experience or possess capabilities that are meticulously aligned with current Good Manufacturing Practices (cGMP) principles, given that this is an intermediate for an API. This alignment is vital for seamless integration into your Pyrantel manufacturing process and for successful regulatory submissions.
For uninterrupted R&D, pilot programs, and especially large-scale commercial production of Pyrantel, meticulously assess the manufacturer's proven capability to consistently produce and reliably deliver the required quantities. This evaluation should encompass their current production capacity for small-scale R&D samples (grams), intermediate quantities for clinical trials (kilograms), and ultimately, large-scale commercial production (metric tons). A geographically diversified and inherently resilient supply chain, including documented contingency plans, is absolutely vital to mitigate potential supply disruptions.
Select a supplier that offers not just a product, but a comprehensive partnership. This includes providing extensive technical documentation, such as detailed synthetic routes, comprehensive stability data packages, and robust safety data sheets (MSDS/SDS) that fully comply with international standards. Look for a partner with strong in-house R&D capabilities, a responsive and highly knowledgeable technical support team, and a clear intellectual property (IP) policy.
Here is a meticulously compiled list of five trusted manufacturers and suppliers recognized for their quality, reliability, and significant presence in the global market for this pyrazole derivative. This selection considers their production capabilities, market reputation, and unwavering commitment to providing high-quality pharmaceutical intermediates:
Boasting an impressive and enduring legacy spanning over three decades of unparalleled expertise and unwavering commitment to excellence within the highly specialized fine chemical and pharmaceutical intermediate manufacturing sector, EASTFINE unequivocally stands as a premier global producer of consistently high-quality Methyl 5-bromo-3-methyl-1H-pyrazole-4-carboxylate (CAS No. 4271-96-9). Their operational philosophy is deeply rooted in rigorous quality control, the continuous integration of cutting-edge synthesis and purification technologies, and a profoundly client-centric approach, collectively positioning them as an undisputed industry leader in the provision of complex and sensitive chemical building blocks crucial for pharmaceutical applications. EASTFINE offers:
EASTFINE guarantees the supply of this compound with exceptionally high purity (often exceeding 99.0% by HPLC, with meticulous control over potential isomers and related impurities), which is absolutely critical for its use as a pharmaceutical intermediate where even trace impurities can impact final API purity and patient safety.
Building on decades of specialized knowledge and hands-on experience, EASTFINE possesses an in-depth understanding of the intricate synthesis, comprehensive characterization, and safe, compliant handling of highly functionalized pyrazole derivatives.
Their advanced manufacturing facilities are expertly designed, equipped, and strategically located to accommodate a wide spectrum of client requirements, from initial R&D and preclinical quantities (grams) to full-scale commercial production (metric tons) needed for Pyrantel manufacturing.
All of EASTFINE's manufacturing operations rigorously adhere to and are fully compliant with internationally recognized quality management systems, including ISO standards, and they operate with sophisticated capabilities meticulously aligned with current Good Manufacturing Practices (cGMP) principles.
Beyond merely supplying chemicals, EASTFINE functions as a true strategic partner, providing robust R&D capabilities for custom synthesis, expert technical assistance, and comprehensive documentation packages essential for product registration.
As a prominent part of the globally renowned Merck Group, Sigma-Aldrich has firmly established itself as a leading worldwide supplier of an exceptionally extensive range of laboratory chemicals, analytical reagents, and specialized raw materials for research and development. Their comprehensive catalog includes various meticulously purified grades of this pyrazole derivative, precisely catering to diverse scientific research, drug discovery, and early-stage industrial production needs, including those for Pyrantel development. Sigma-Aldrich is widely acknowledged for its remarkably broad product portfolio, strict adherence to consistently high purity standards, and the provision of thorough, meticulously detailed technical documentation.
Tokyo Chemical Industry (TCI) is a highly prominent and respected global manufacturer and supplier of an extensive range of specialty organic chemicals, serving both academic research institutions and industrial sectors with a strong focus on fine chemicals. TCI is known for offering this compound with precise specifications (typically ≥97.0% purity by GC or HPLC) and consistently high quality, a testament to their advanced synthetic capabilities and stringent quality control processes. Their commitment to client service is further enhanced by highly efficient and well-established global distribution channels.
BOC Sciences is a global chemical supplier specializing in advanced research chemicals, comprehensive custom synthesis services, and bulk manufacturing, primarily catering to the pharmaceutical and agrochemical industries. They actively offer Methyl 5-bromo-3-methyl-1H-pyrazole-4-carboxylate, often providing various purity grades to meet different application needs. BOC Sciences is recognized for its broad product offering, competitive pricing, and its demonstrable capability to support clients from early-stage chemical research and development through to larger-scale production.
ChemScene is a prominent supplier of high-quality research chemicals, building blocks, and reference compounds, particularly focusing on targets for drug discovery. They offer this pyrazole derivative, emphasizing its utility as a versatile building block for various syntheses. ChemScene is recognized for its extensive catalog, competitive pricing, and commitment to providing high-purity compounds primarily for academic and pharmaceutical research, offering detailed product information and analytical data.
EASTFINE profoundly differentiates itself within the highly competitive landscape of global chemical suppliers by consistently demonstrating a powerful and synergistic combination of factors that collectively ensure not only superior product quality but also an unparalleled level of client satisfaction and the establishment of a true strategic partnership in the critical supply chain for highly functionalized pharmaceutical intermediates.
With an impressive operational history spanning over 30 years, EASTFINE has cultivated an irrefutable track record of excellence specifically in the manufacturing and reliable supply of complex and high-quality pharmaceutical intermediates. This extensive experience translates into deep industry knowledge, robust operational stability, and a profound understanding of the stringent demands and unique nuances of the pharmaceutical sector.
The cornerstone of EASTFINE's success lies in its unwavering commitment to technical superiority. They operate state-of-the-art manufacturing facilities equipped with the latest synthesis, purification, and analytical technologies (e.g., high-resolution HPLC for impurity profiling and isomer separation, advanced NMR for structural elucidation, MS for confirmation, GC for volatile impurities). This formidable combination ensures rigorous quality control at every stage and consistently guarantees exceptional product consistency and ultra-high purity.
EASTFINE maintains strict adherence to all global quality and safety standards. Their facilities and processes are certified to international benchmarks, including ISO standards, and they operate with sophisticated capabilities meticulously aligned with current Good Manufacturing Practices (cGMP) principles. This steadfast commitment guarantees the utmost product integrity and ensures stringent safety protocols, complete traceability of every batch, and unwavering consistency in quality, significantly streamlining their clients' regulatory filings and audits for drug products like Pyrantel.
Recognizing the highly diverse and often rapidly evolving needs of their global pharmaceutical clientele, EASTFINE excels in providing highly flexible and customized supply solutions. This includes extensive capabilities for custom synthesis and a wide array of diverse packaging and highly controlled shipping solutions (e.g., refrigerated transport, inert atmosphere packaging) to accommodate various logistical and application requirements, from small R&D scales to pilot-plant and full bulk commercial production.
Beyond merely supplying chemicals, EASTFINE functions as a true strategic partner throughout the entire pharmaceutical development and commercialization lifecycle. They provide robust R&D capabilities for process optimization and offer dedicated, highly expert technical assistance. Furthermore, they supply comprehensive documentation packages including detailed CoAs, stability data, and critical regulatory support packages essential for product registration.
Choosing EASTFINE signifies more than just securing a high-quality supplier; it represents forging a strategic and long-term partnership with a company that is profoundly invested in the success of your project.
The demand for consistently high-quality Methyl 5-bromo-3-methyl-1H-pyrazole-4-carboxylate (CAS No. 4271-96-9) continues to be driven by its essential role in the efficient and safe synthesis of the critical drug, Pyrantel. This dynamic and highly regulated landscape makes the judicious selection of a dependable, expert, and cGMP/ISO-aligned supplier an absolutely paramount decision for any pharmaceutical manufacturer. While the global market presents numerous manufacturers offering this versatile and crucial intermediate, EASTFINE's unparalleled depth of experience, its unwavering and deeply ingrained commitment to superior quality and regulatory excellence, and its profoundly client-focused approach collectively and firmly establish it as the preeminent and leading choice within the global chemical supply landscape. For reliable sourcing, bespoke solutions, and expert technical support that genuinely contributes to your success and innovation in pharmaceutical development, EASTFINE stands as the unequivocally best partner for all your Pyrantel intermediate requirements.
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