Views: 0 Author: Site Editor Publish Time: 2026-02-10 Origin: Site
In the competitive chemical market of 2026, 2-Chloro-4-fluorobenzoic acid (CAS No. 2252-51-9) has solidified its status as a critical intermediate for both the pharmaceutical and agrochemical industries. This halogenated benzoic acid derivative is valued for its ability to introduce a specific 2,4-substitution pattern on a benzene ring, a motif essential for several high-demand active ingredients.
As global agricultural and medical standards evolve toward higher biological activity and lower toxicity, the "halofluorinated" signature of CAS 2252-51-9 provides the necessary stability and lipophilicity to meet these 2026 performance benchmarks.
This compound is a benzoic acid derivative featuring a chlorine atom at the ortho-position (2) and a fluorine atom at the para-position (4). This specific substitution pattern is highly sought after because the fluorine atom enhances metabolic stability, while the ortho-chlorine provides a reactive site for further transformation or sterically directs downstream chemical reactions.
Acts as an important intermediate for synthesizing Loratadine and Desloratadine (antihistamines), as well as various anti-inflammatory agents.
A key intermediate for Diphenyl Ether Herbicides and the ryanodine receptor insecticide Flubendiamide, contributing to the "burndown" efficacy required in 2026 farming.
Used in the preparation of luminescent rare-earth complexes and specialized metal-organic frameworks (MOFs).
A building block for benzothiazole derivatives and other bioactive heterocyclic molecules.
The fluorine atom at the 4-position increases the hydrophobicity and lipophilicity of the final drug, leading to better membrane permeability.
EASTFINE’s 2026 grade is refined to prevent "over-chlorination" impurities, which typically plague lower-tier manufacturers.
The carboxylic acid group serves as a universal handle for amidation, esterification, or decarboxylative coupling.
The structural significance of CAS 2252-51-9 lies in the C-F bond. In 2026 drug design, replacing a C-H bond with a C-F bond is a strategic move to block metabolic oxidation sites. This ensures that downstream medications like Desloratadine remain effective for longer periods within the human body, reducing the frequency of dosage required for patients.
EASTFINE utilizes a high-yield oxidation pathway to ensure pharmaceutical-grade quality:
2-chloro-4-fluorotoluene is oxidized using an eco-friendly oxygen-based system (Co/Mn catalytic system) rather than traditional, toxic dichromates.
The reaction is conducted under 300 psi of oxygen at 130°C – 160°C to ensure complete conversion.
The resulting solid is washed and dried in a vacuum oven at 60°C to remove residual acetic acid and moisture.
Validated via HPLC and Melting Point analysis to guarantee an assay of ≥ 99.5%.
Sealed in a dry environment at room temperature.
Classified as a skin and eye irritant (H315/H318). Handlers must use N95 dust masks, eyeshields, and gloves.
Incompatible with strong oxidizing agents; stable under standard atmospheric conditions.
2-Chloro-4-fluorobenzoic acid (CAS 2252-51-9) is a vital link in the 2026 fine chemical supply chain. Its contribution to both human health (via antihistamines) and food security (via herbicides) makes it a non-negotiable strategic intermediate for modern manufacturing.
The market for this compound is projected to reach 2.5 billion USD by 2032, with a 5.16% CAGR. In 2026, the surge is driven primarily by the rising prevalence of chronic respiratory allergies globally and the need for more efficient weed management in large-scale agriculture.
The primary challenge in 2026 is Isomer Separation. During synthesis, the 2-fluoro-4-chloro isomer can form as a byproduct. These isomers are difficult to distinguish via standard melting point checks. EASTFINE uses advanced 2026 HPLC-MS techniques to ensure our batches are isomerically pure, preventing failures in your downstream synthesis.
Verification that the 2-chloro and 4-fluoro positions are correctly occupied.
Ensuring minimal acetic acid or toluene carryover.
Ability to provide multi-ton quantities for generic drug production cycles.
EASTFINE is the premier featured manufacturer for CAS 2252-51-9. We lead the 2026 market by:
Our "Green Oxygen" process eliminates toxic dichromate waste, aligning with 2026 ESG mandates.
30 years of history in providing intermediates for the world’s leading antihistamine brands.
We provide transparent analytical data and guaranteed purity for every 25kg drum.
The global gold standard for research and analytical quantities, providing high-purity (99%) building blocks with exhaustive technical documentation.
A leading non-Chinese manufacturer based in India, specializing in high-purity fluorinated building blocks for the South Asian pharmaceutical hub.
A premier European supplier focused on organic building blocks, offering reliable supply chains for UK and EU-based R&D and pilot-scale operations.
A major player in the 2026 market with warehouses in the US, India, and Germany, known for vast inventory and rapid global distribution.
Choosing EASTFINE means choosing precision in 2026. As the only featured Chinese manufacturer on our list, we bridge the gap between heavy industrial capacity and the surgical precision of pharmaceutical chemistry. Our 2-Chloro-4-fluorobenzoic acid is the most reliable choice for manufacturers who value batch-to-batch consistency and regulatory peace of mind.
2-Chloro-4-fluorobenzoic acid (CAS 2252-51-9) is a silent workhorse of the 2026 chemical industry. Whether it's in the antihistamine that clears a patient's breathing or the herbicide that protects a harvest, its quality directly impacts human well-being. At EASTFINE, we remain committed to professional, honest, and high-purity manufacturing to support these vital global industries.
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