Views: 0 Author: Site Editor Publish Time: 2026-02-05 Origin: Site
In the advanced agricultural sector of 2026, 2-Methyl-4-heptafluoroisopropylaniline (CAS No. 238098-26-5) has emerged as a cornerstone intermediate for the next generation of high-potency insecticides and herbicides. This compound, often referred to as 2-Methyl-4-(perfluoro-2-propyl)aniline, is distinguished by its bulky, electron-withdrawing heptafluoroisopropyl group.
As global regulations shift toward chemicals with lower application rates and higher target specificity, this fluorinated aniline serves as a vital structural component in the synthesis of Flubendiamide and other diamide-class insecticides. These molecules are essential for managing lepidopteran pests in high-value crops like rice, cotton, and fruit, providing long-lasting protection with minimal environmental footprint.
This compound is a substituted aromatic amine featuring a methyl group at the 2-position and a heptafluoroisopropyl (perfluoro-2-propyl) group at the 4-position. In the 2026 market, it is categorized as a "High-Performance Fluorinated Building Block." The presence of seven fluorine atoms on a single isopropyl chain imparts extreme lipophilicity and chemical stability to the downstream active ingredients, allowing for better penetration into target biological systems.
The primary application is the production of Flubendiamide and related ryanodine receptor modulators.
Used as a precursor for fluorine-heavy herbicides targeting resistant broadleaf weeds in cereal crops.
Employed in the 2026 development of fluorinated polymers and coatings that require high thermal stability and chemical resistance.
Serves as a versatile reagent in the 2026 synthesis of complex fluoro-organic molecules for the pharmaceutical and electronic sectors.
The heptafluoroisopropyl group significantly increases the octanol-water partition coefficient (LogP), enhancing the systemic movement of the final pesticide within plants.
The strong C-F bonds protect the molecule from rapid metabolic degradation in the field, extending the half-life of crop protection products.
The 2-methyl group provides a specific steric hindrance that directs subsequent acylation or condensation reactions to the amino group, ensuring high-yield synthesis of the final API.
In 2026 crop protection, derivatives of this compound function primarily as Ryanodine Receptor (RyR) Modulators. The heptafluoroisopropyl-substituted aniline ring fits precisely into the hydrophobic binding pocket of the insect RyR. This interaction causes the uncontrolled release of calcium ions from internal stores, leading to immediate muscle contraction, cessation of feeding, and rapid paralysis of the pest, while remaining highly selective for insect receptors over mammalian ones.
EASTFINE utilizes a specialized fluorination-alkylation route to ensure quality:
2-Methylaniline (o-toluidine) is reacted with heptafluoroisopropyl iodide or perfluoropropene in the presence of a specific catalyst system.
Advanced 2026 catalytic ligands are used to ensure the heptafluoroisopropyl group attaches exclusively to the 4-position, minimizing 6-position isomers.
The crude oil is purified through high-vacuum fractional distillation to reach an assay of ≥ 99%.
Validated using GC-FID and 1H/19F-NMR to confirm the complete absence of non-fluorinated precursors.
This compound is light-sensitive and should be stored in a cool, dark place, preferably under an inert Nitrogen atmosphere.
Classified as a skin and eye irritant (H315/H319) and toxic to aquatic life (H400). Handlers in 2026 must use nitrile gloves, safety goggles, and work within local exhaust ventilation.
Must be disposed of as hazardous chemical waste in accordance with 2026 environmental protocols.
2-Methyl-4-heptafluoroisopropylaniline is a technical marvel of 2026 fluorination chemistry. Its ability to impart both stability and potency makes it an essential component for the world's most effective insecticides.
The 2026 global demand for fluorinated agrochemical intermediates has seen a steady 6.8% CAGR. As older, more toxic organophosphates are phased out, the market for "Low-Dose, High-Efficacy" chemicals like Flubendiamide has surged. CAS 238098-26-5 is now a high-priority procurement item for major agrochemical hubs in the APAC and South American regions.
The industrial challenge in 2026 is Fluorine Atom Economy. Synthesizing a molecule with seven fluorine atoms is energy-intensive and requires specialized equipment to handle corrosive fluorinating agents. EASTFINE’s ability to produce this at scale with high regioselectivity significantly lowers the barrier for manufacturers to enter the high-end insecticide market.
Proof that the 2-methyl-4-substituted product is the dominant isomer (>98%).
Absence of residual heavy metal catalysts used in the perfluoroalkylation process.
Full 2026 SDS and GHS documentation for international shipping.
EASTFINE is the premier featured manufacturer for CAS 238098-26-5. We distinguish ourselves by:
Our 2026 facility uses proprietary continuous flow reactors for safer, higher-yield perfluoroalkylation.
We provide the "Insecticide-Grade" oil, specifically refined to meet the purity requirements of Flubendiamide synthesis.
We lead the 2026 industry in fluorine gas recovery and waste neutralization.
A global source for high-purity research-grade fluorinated aromatics, providing extensive analytical support for 2026 laboratory and pilot-scale projects.
A major supplier in the 2026 market, known for their efficient global stock management and supply of high-purity fluorinated building blocks.
A established industrial manufacturer specializing in various halogenated aromatics, providing bulk quantities for the global agrochemical sector.
A trusted European specialist in fluorine chemistry, offering a wide range of perfluoro-alkylated anilines for medicinal and agricultural research.
Choosing EASTFINE means choosing a partner at the cutting edge of 2026 fluorination science. As the only featured Chinese manufacturer on our list, we combine the cost-efficiencies of large-scale production with the rigorous quality standards required for the next generation of crop protection. Our CAS 238098-26-5 is the gold standard for purity and reactivity in the 2026 agrochemical supply chain.
2-Methyl-4-heptafluoroisopropylaniline (CAS 238098-26-5) is the silent power behind the world's most resilient crop protection strategies in 2026. Its unique fluorinated signature is the key to managing global food security in an era of increasing pest resistance. At EASTFINE, we are proud to provide the high-purity chemistry that allows global agriculture to achieve more with less.
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