Views: 0 Author: Site Editor Publish Time: 2026-03-12 Origin: Site
In the sophisticated chemical landscape of 2026, the demand for high-performance molecules has shifted from simple bulk reagents to highly specialized building blocks. N-Isopropylmethylamine (CAS 4747-21-1), also known as Methyl(isopropyl)amine, stands at the forefront of this shift. This secondary aliphatic amine is a structural masterpiece, combining the high nucleophilicity of a methylamine with the strategic steric bulk of an isopropyl group.
As global pharmaceutical and agrochemical industries move toward "Smart Molecules"—compounds that are more bioavailable, metabolically stable, and environmentally benign—N-Isopropylmethylamine has become the reagent of choice for introducing the N-methyl-isopropyl moiety. In 2026, this structural unit is a key feature in over 40 new API (Active Pharmaceutical Ingredient) patents, particularly in the field of central nervous system (CNS) modulators and high-efficiency herbicides. At EASTFINE, we have scaled our production to meet this surge, ensuring that our partners have access to the highest purity material available in the global market.
N-Isopropylmethylamine is a low-molecular-weight secondary amine with the formula C4H11N. It presents as a colorless to pale-yellow, highly volatile liquid. Its molecular structure—a nitrogen atom bonded to a methyl group (CH3) and an isopropyl group (CH(CH3)2)—creates a unique "V-shaped" electronic profile.
Molecular Weight: 73.14 g/mol
Boiling Point: 50°C – 53°C (Extremely volatile)
Specific Gravity: 0.702 at } 25°C
Basicity (pKa): Approximately 11.0, making it a strong organic base.
The inclusion of the isopropyl group at the 4-position of the nitrogen atom is not accidental. In 2026 medicinal chemistry, this group acts as a "Steric Shield." By crowding the nitrogen atom, the isopropyl group protects the molecule from rapid metabolic degradation in the liver (specifically by the cytochrome P450 enzyme system). This increases the drug's half-life, allowing for lower doses and fewer side effects for the patient.
The synthesis of high-purity N-Isopropylmethylamine is a technical challenge that requires precision to avoid the formation of primary or tertiary amine byproducts.
Traditionally, the synthesis involves two main pathways:
Reacting Acetone with Methanol-based Methylamine over a metal catalyst (usually Ni or Pd) under high hydrogen pressure.
Reacting Isopropylamine with Dimethyl Carbonate (DMC) or Methanol.
In 2026, EASTFINE has transitioned away from traditional batch processing. Our proprietary synthesis utilizes Vapor-Phase Continuous Flow Catalysis. This method offers several critical advantages:
By controlling the contact time with the catalyst to within milliseconds, we ensure that 99.5%+ of the product is the desired secondary amine, virtually eliminating N,N-dimethylisopropylamine (the tertiary byproduct).
Our process achieves an efficiency rate of 98.2%, significantly reducing waste and lowering the overall carbon footprint of your supply chain.
Traditional amination produces water as a byproduct. EASTFINE’s 2026 drying technology utilizes in-line molecular sieves to deliver a product with < 200 ppm water content, essential for sensitive anhydrous reactions.
In 2026, N-Isopropylmethylamine is a critical intermediate for:
Used in the synthesis of novel tryptamines and antidepressants. The N-methyl-isopropyl group allows the molecule to cross the blood-brain barrier more effectively.
A building block for next-generation beta-blockers and anti-arrhythmic agents.
Utilized in the generation of in situ micelles for stimuli-responsive drug delivery, a cutting-edge field in 2026 personalized medicine.
The agrochemical industry uses CAS 4747-21-1 to create selective herbicides. The bulky isopropyl group ensures that the herbicide targets specific plant enzymes without affecting neighboring crops, aligning with 2026's "Precision Agriculture" mandates.
The high volatility and chemical reactivity of N-Isopropylmethylamine demand the most rigorous safety protocols in the industry. As of 2026, all handling must comply with the updated GHS Revision 11 standards.
Highly flammable liquid and vapor (H225). The flash point is a dangerous -32°C.
Toxic if swallowed (H301) or inhaled (H331).
Causes severe skin burns and serious eye damage (H314).
At EASTFINE, we mandate a "Closed-System Only" protocol for CAS 4747-21-1:
Use of stainless steel, pressure-tested piping with dry-disconnect couplings to prevent even trace leaks.
The compound is air-sensitive and can react with atmospheric CO2 to form carbamates. Always handle under a high-purity Nitrogen or Argon blanket.
Store in explosion-proof refrigerators or climate-controlled warehouses at temperatures < 15°C.
Standard nitrile is a failure point for volatile amines. 2026 standards require Butyl Rubber or Viton® gloves (>0.7 mm thickness) for any potential contact.
If handled outside a closed system, a full-face Powered Air-Purifying Respirator (PAPR) with an "Amine-Specific" cartridge is mandatory.
Flame-resistant, anti-static, and chemical-impervious coveralls (Category III Type 3/4).
Use non-sparking tools and "Wet-Absorption" methods. Absorb with dry sand or vermiculite. Do not use sawdust.
Immediate irrigation of eyes/skin for 30 minutes. Because of the "Lipophilic Trap" effect of the isopropyl group, dermal contact requires medical observation for at least 6 hours to monitor for systemic absorption.
| Property | Value / 2026 Standard |
|---|---|
| CAS Number | 4747-21-1 |
| Assay (GC) | ≥ 99.5% |
| Water Content | ≤ 200 ppm |
| Flash Point | -32 °C (Closed Cup) |
| Density (20/ 20°C) | 0.70 |
| Appearance | Colorless, clear liquid |
| Refractive Index (n20/D) | 1.384 |
In the precision-driven chemical market of 2026, the quality of your intermediate is the quality of your brand. EASTFINE Precision Chemistry is more than just a manufacturer; we are your strategic partner in amine chemistry.
Our continuous flow synthesis ensures that you receive a product with zero tertiary amine contamination, protecting your downstream yields.
We ship in specialized, pressure-tested stainless steel drums with internal fluorinated liners to ensure 100% container integrity during long-distance transit.
Every batch of EASTFINE N-Isopropylmethylamine is accompanied by a 2026-compliant SDS, a detailed CoA, and a REACH-compliant dossier for European markets.
For over 30 years, we have provided pharmaceutical and agrochem intermediate companies with the building blocks they need to succeed. Our commitment to Honesty, Professionalism, and Collaboration is why the world’s leading chemical firms choose EASTFINE.
N-Isopropylmethylamine (CAS 4747-21-1) is a small molecule that carries the weight of modern innovation. From its strategic role in pharmaceutical metabolism to its critical importance in precision agriculture, it is an essential component of the 2026 chemical economy. By adhering to the rigorous safety protocols outlined here and sourcing your material from a technical leader like EASTFINE, you ensure that your facility is safe, your products are superior, and your business is built for the future.
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