Views: 0 Author: Site Editor Publish Time: 2026-01-30 Origin: Site
As we navigate through 2026, the demand for precision in agrochemical formulation has never been higher. 2-Methyl-1-methylthio-2-propylamine (CAS 36567-04-1) is the strategic intermediate that allows for the creation of molecules with both high lipophilicity and specific hydrogen-bonding capacity.
By integrating a methylthio (-SCH3) group with a tertiary-alkyl amine, this compound serves as the structural foundation for Flubendiamide, a premier insecticide used to safeguard global crops against lepidopterous pests. In 2026, its application has branched out into specialized epoxy curing agents and the development of next-generation anti-epilepsy drugs.
It is a primary aliphatic amine where the nitrogen atom is attached to a sterically hindered tertiary carbon (the 2-position of a propane chain). The terminal carbon (the 1-position) is substituted with a methylsulfanyl group. This structure, CH3SCH2C(CH3)2NH2, is prized for its ability to participate in clean acylation reactions while maintaining the metabolic stability provided by the sulfur atom.
The vital intermediate for synthesizing Flubendiamide, a phthalic acid diamide insecticide that targets ryanodine receptors.
Used in the R&D of anti-epilepsy drug candidates, where the branched alkyl chain improves blood-brain barrier (BBB) penetration.
Acts as a high-performance epoxy resin curing agent, providing superior thermal resistance and chemical durability in industrial coatings.
Employed in the 2026 dye industry to modify chromophores and improve the light-fastness of specialized industrial pigments.
The twin methyl groups at the alpha-position shield the amine nitrogen, preventing unwanted side reactions during complex synthesis.
The methylthio group increases the log P of final compounds, which in 2026 is a key strategy for improving the systemic movement of pesticides within plants.
Its primary amine is highly reactive toward acid chlorides and anhydrides, facilitating high-yield coupling even in large-scale industrial reactors.
In the context of 2026 insect science, derivatives of this compound function as Ryanodine Receptor (RyR) Modulators. The 2-methyl-1-methylthio-2-propylamine moiety acts as a hydrophobic anchor, allowing the insecticide to bind deeply within the receptor's transmembrane domain. This causes an uncontrolled release of internal calcium stores, leading to the rapid cessation of feeding and eventual paralysis of the target pest.
EASTFINE utilizes a high-efficiency synthetic route to ensure 2026-compliant purity:
Reaction of isobutylene-derived precursors with sodium thiomethoxide (NaSCH3).
Introduction of the amine group through a high-pressure amination process or via an oxime-reduction pathway.
The crude product is refined through a multi-stage fractional distillation to remove all trace sulfur byproducts.
Final product is validated via GC-FID and H-NMR to confirm the absence of isomeric impurities.
Due to its pungent sulfurous odor, it must be handled in a closed-loop system with activated carbon scrubbers.
Store in 200L Galvanized Drums under an inert nitrogen atmosphere at 2°C – 8°C.
This compound is corrosive and toxic (H311/H314). Personnel must use full chemical-resistant suits and Viton gloves.
(CAS 36567-04-1) is a testament to the power of functionalized aliphatics. Its unique role in securing the global food supply through Flubendiamide synthesis makes it a high-priority intermediate for the 2026 chemical market.
The 2026 demand for this compound is driven by the expansion of the "Green Agrochemical" sector. With a 6.8% CAGR, the market is particularly strong in Brazil and India, where large-scale rice and soybean production relies heavily on the insecticides derived from this high-purity amine.
The primary challenge in 2026 industrial use is Moisture and Purity Consistency. Even trace amounts of water (≥ 0.5%) can deactivate the catalysts used in the downstream synthesis of insecticides. High-purity CAS 36567-04-1 from EASTFINE ensures that industrial production remains efficient and cost-effective.
Minimal Moisture: Must be ≤ 0.1% for critical applications.
Total Impurities (GC): ≤ 0.5% to prevent toxic byproduct formation.
Regulatory Compliance: Full REACH and GHS-2026 documentation is mandatory.
EASTFINE is the #1 featured manufacturer for CAS 36567-04-1. We provide:
Our 2026 capacity exceeds 100 tons per annum.
Every batch is accompanied by a comprehensive COA and H-NMR report.
Customized Logistics:Shipping in sealed, galvanized 200L drums to maintain odor control and chemical integrity.
A world-class non-Chinese manufacturer specializing in high-purity pharmaceutical-grade intermediates and complex impurity standards for the global market.
A trusted European supplier offering high-purity research chemicals and building blocks, recognized for excellence in fluorinated and sulfur-containing intermediates.
A prominent Hyderabad-based manufacturer providing industrial-scale quantities of 2-Methyl-1-methylthio-2-propylamine with a focus on bulk agrochemical and paint applications.
A leading global manufacturer of high-quality drug intermediates and reference standards, supporting large-scale pharmaceutical projects with comprehensive analytical data.
Choosing EASTFINE means partnering with a 30-year veteran of the fine chemical industry. In 2026, we remain dedicated to the "Honesty and Professionalism" that ensures your chemical supply chain is as reliable as your final product.
2-Methyl-1-methylthio-2-propylamine is a foundational pillar of 2026 agrochemical and pharmaceutical innovation. At EASTFINE, we take pride in delivering the purity that makes global health and agricultural success possible.
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