EASTFINE has been a dedicated manufacturer for high-purity 372-29-2 Ethyl 3-amino-4,4,4-trifluoro-2-butenoate (also known as Ethyl 3-amino-4,4,4-trifluorocrotonate) since 1995. As a professional chemical enterprise, we specialize in providing this essential fluorinated building block. Its unique trifluoromethyl, amine, and enoate functionalities make it indispensable for synthesizing complex CF3-containing heterocycles in pharmaceutical and agrochemical research. Our commitment to quality ensures reliable supply and professional service for clients across Asia, America, and Europe.
372-29-2
Agrochemical Intermediate
Ethyl 3-amino-4,4,4-trifluoro-2-butenoate
≥98%
C6H8F3NO2
183.13 g/mol
White solid or colorless to pale yellow low-melting liquid
24−26 °C
83−85 °C/15 mmHg
1.245 g/cm3
Store at 2−8 °C, protected from light.
200L Galvanized Drum
Contact us for Customized Packaging
Please contact us
Availability: | |
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Product Description
As a leading supplier of Fluorinated Building Blocks, EASTFINE is a trusted partner and 372-29-2 Ethyl 3-amino-4,4,4-trifluoro-2-butenoate manufacturer. This compound, featuring a strategic combination of a trifluoromethyl (CF3) group, an amine (NH2), and an unsaturated ester (C=C−CO2Et), is a vital, highly reactive intermediate. It is extensively used in cyclization reactions to form advanced pharmaceutical and agrochemical structures, such as quinolinones and oxazinones. Our specialized production capabilities ensure the highest standards of quality and purity required for these demanding synthetic applications.
At EASTFINE, our 372-29-2 Ethyl 3-amino-4,4,4-trifluoro-2-butenoate is produced under strict quality control to guarantee its performance. The product’s consistent properties are critical for its use in the synthesis of advanced fluorine-containing molecules.
CAS No. | 372-29-2 |
Category | Agrochemical Intermediate |
Name | Ethyl 3-amino-4,4,4-trifluoro-2-butenoate |
Molecular Formula | C6H8F3NO2 |
Molecular Weight | 183.13 g/mol |
Chemical Structure | ![]() |
Form | White solid or colorless to pale yellow low-melting liquid |
Melting Point | 24−26 °C |
Boiling Point | 83−85 °C/15 mmHg |
Density | 1.245 g/cm3 |
Storage Temperature | Store at 2−8 °C, protected from light. |
Packaging | 200L Galvanized Drum |
Contact us for Customized Packaging | |
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MSDS document |
As a dedicated 372-29-2 Ethyl 3-amino-4,4,4-trifluoro-2-butenoate manufacturer, EASTFINE guarantees a stable supply chain crucial for your commercial-scale production. Our operations are supported by our dedicated production facility, which specializes in fluorinated and chiral intermediates, ensuring consistent, scalable output. The production process adheres to GMP-LIKE quality standards, and every batch undergoes comprehensive quality assurance testing to verify purity (min. 97%) and stability. Our extensive warehouse capabilities ensure secure storage and reliable, on-time delivery of your orders globally.
The trifluoromethyl group is highly valued for its ability to significantly alter the properties of a molecule. It enhances metabolic stability, increases lipophilicity (improving bioavailability in drugs and systemicity in agrochemicals), and is a powerful electron-withdrawing group, influencing the reactivity and pKa of adjacent functional groups, making it a cornerstone in modern drug discovery and pesticide development.
The 3-amino-2-butenoate structure represents a vinylogous urethane/amide, making it a highly versatile enamine intermediate. It is often used in condensation and cyclization reactions with other functional groups (like acid chlorides or isocyanates) to rapidly construct nitrogen-containing heterocycles, which form the core structure of many bioactive compounds.
Due to its low melting point and the reactive nature of the enamine and ester groups, this compound should be stored between 2−8 °C in a tightly sealed container. It should also be protected from light and moisture to prevent degradation, ensuring its high purity is maintained until use.
Established in 1995, EASTFINE has evolved into a leading enterprise in the production of fine and specialty chemicals. As a dedicated 372-29-2 Ethyl 3-amino-4,4,4-trifluoro-2-butenoate manufacturer, we are committed to providing reliable solutions for a diverse range of industries. Our company operates on the core principles of honesty, professionalism, and collaboration, which guide our interactions with a global client base spanning Asia, America, and Europe. We strive to be a trusted partner in providing high-quality chemical intermediates.
The EASTFINE team consists of highly skilled technical experts and customer-focused sales professionals. We are committed to providing exceptional service and comprehensive technical support for products like 372-29-2 Ethyl 3-amino-4,4,4-trifluoro-2-butenoate. Our team proactively manages logistics, quality assurance documentation, and regulatory compliance to ensure a smooth and efficient procurement process. We aim to build long-term partnerships based on mutual trust and support.
EASTFINE’s manufacturing strength for products like 372-29-2 Ethyl 3-amino-4,4,4-trifluoro-2-butenoate is built on a flexible and efficient model. This combines the capabilities of our own dedicated production base with strategically managed outsourced processing, allowing us to meet a wide range of order sizes. Our manufacturing processes adhere to GMP-LIKE standards, and we are committed to continuous investment in technology to enhance purity and yield, ensuring consistent quality for all our products.
At EASTFINE, our advanced R&D system is focused on creating new synthesis routes and improving existing processes for products like 372-29-2 Ethyl 3-amino-4,4,4-trifluoro-2-butenoate. Our state-of-the-art pilot and Kilo-Lab facilities allow for a seamless transition from laboratory research to commercial production. Quality assurance is integrated into every stage of our R&D process, ensuring that quality is built into the product from its inception.
Our business is driven by a core set of values that define our approach to every project, including the supply of 372-29-2 Ethyl 3-amino-4,4,4-trifluoro-2-butenoate.
EASTFINE is committed to a robust culture of intellectual property (IP) protection. As a 372-29-2 Ethyl 3-amino-4,4,4-trifluoro-2-butenoate manufacturer, we understand the importance of safeguarding confidential synthesis routes and proprietary information. Our active patent portfolio, which includes 19 invention patents and 8 utility model patents, is a testament to our dedication to innovation. This strong IP framework ensures we can handle your most sensitive projects with complete confidentiality and professionalism.
EASTFINE aims to leverage its global presence and logistics network to support reliable and efficient delivery of 372-29-2 Ethyl 3-amino-4,4,4-trifluoro-2-butenoate to clients across Asia, America, and Europe. Our approach to supply chain management, combined with strategic warehousing and a dual manufacturing method, is designed to provide consistent supply and support on-time delivery, seeking to minimize any potential disruptions for your operations.
To accommodate our diverse international client base, EASTFINE offers flexible payment methods. While specific terms can be discussed upon quotation, we generally accept common secure payment options such as bank transfers (T/T). Our sales team is ready to discuss mutually agreeable payment solutions for your 372-29-2 Ethyl 3-amino-4,4,4-trifluoro-2-butenoate order.
Yes, customized synthesis and OEM services are key offerings at EASTFINE. As a 372-29-2 Ethyl 3-amino-4,4,4-trifluoro-2-butenoate manufacturer, our dedicated Custom Synthesis Department, backed by our advanced R&D and production base, is equipped to provide comprehensive support. Whether you require a specialized variant of this chemical or other unique compounds, we aim to offer solutions including logistics, quality control, and new product development tailored to your specific project needs.
Yes, EASTFINE operates with transparency and welcomes client audits. Our production of pharmaceutical intermediates, including 372-29-2 Ethyl 3-amino-4,4,4-trifluoro-2-butenoate, strives to comply with GMP-LIKE requirements. We aim to build trust through openness and are prepared to demonstrate our adherence to quality and operational considerations during your audit process.
Yes, EASTFINE is an active participant in industry events to connect with our global clients and showcase our advancements. We regularly attend CPHI (Convention on Pharmaceutical Ingredients), both domestically and internationally each year. These exhibitions provide an opportunity for face-to-face discussions about your needs for 372-29-2 Ethyl 3-amino-4,4,4-trifluoro-2-butenoate and other chemical solutions, and to explore potential collaborations.
We understand the importance of product evaluation before a large order. To ensure our clients' confidence, samples from our 372-29-2 Ethyl 3-amino-4,4,4-trifluoro-2-butenoate manufacturer are available upon request. Please note that samples are provided on a non-gratis basis. To arrange for a sample of our product and discuss the specific terms, please contact our sales team directly.
EASTFINE is a brand built on a foundation of professional dedication and humble service since 1995. We aim to be a trusted, long-term partner in the fine chemical industry. Our brand identity is defined by our commitment to providing reliable, high-quality products like 372-29-2 Ethyl 3-amino-4,4,4-trifluoro-2-butenoate, supported by technical expertise and ethical business practices.
Our sales team is focused on building sincere and lasting relationships. We prioritize clear, timely, and effective communication throughout the entire process, from initial inquiry to post-delivery support. Our approach is collaborative and transparent, aiming to provide you with a professional and straightforward experience as your partner for 372-29-2 Ethyl 3-amino-4,4,4-trifluoro-2-butenoate and other intermediates.
We view client complaints as opportunities for continuous improvement. EASTFINE is committed to a structured and transparent process for addressing all feedback. We take all complaints seriously, investigate them thoroughly, and work to implement corrective actions to ensure full compliance and client satisfaction. Our goal is to resolve issues quickly and effectively, upholding our core value of responsibility.
Continuous improvement is a core principle of our QA framework. Our Quality Assurance team is involved from the earliest R&D stages, and their oversight continues throughout production. We regularly review our processes against GMP-LIKE standards, incorporating feedback and new technologies to consistently enhance the quality and reliability of our products, including 372-29-2 Ethyl 3-amino-4,4,4-trifluoro-2-butenoate. This expresses our determination to meet and exceed client expectations.
As a responsible chemical enterprise, EASTFINE is committed to operating in an environmentally conscious manner. We strive to implement sustainable practices in our production processes to minimize our ecological footprint. Our dedication to social responsibility is a key part of our "Sustainable Development" core value, reflecting our commitment to the well-being of our community and the planet.