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Top 10 Manufacturers of Pharmaceutical Intermediate CAS No. 872-53-7 in 2025
Top 10 Manufacturers of Pharmaceutical Intermediate CAS No. 872-53-7 in 2025
Views: 0 Author: Site Editor Publish Time: 2025-07-10 Origin: Site
Understanding CAS No. 872-53-7 – A High-Performance Solvent and Versatile Intermediate
CAS No. 872-53-7, known as N-Methyl-2-pyrrolidone (NMP), is a highly polar aprotic solvent widely used as a processing aid, reaction medium, and intermediate in pharmaceutical manufacturing. While NMP is primarily known for its use in synthesis, extraction, and purification, it also serves as a starting material for synthesizing APIs, particularly in central nervous system (CNS) drugs, hormonal agents, and controlled-release formulations.
Due to its excellent solvency power, high boiling point, and miscibility with water and most organic solvents, NMP remains indispensable in modern pharmaceutical production.
Importance of CAS No. 872-53-7 in Pharmaceutical Manufacturing
Critical Solvent in API Synthesis
NMP facilitates reactions involving poorly soluble compounds and is commonly used in peptide and polymer drug synthesis.
Intermediate for CNS and Antiviral Agents
Serves as a chemical precursor in certain CNS-active drugs and antiviral intermediates.
Excellent Solubility Profile
Compatible with a wide variety of compounds, making it a preferred solvent in reaction steps and formulation.
Widely Accepted in Formulation Science
Used in transdermal patches, injectable drugs, and sustained-release systems due to its penetration-enhancing properties.
Subject to Tight Regulatory Control
Due to potential reproductive toxicity, its use is strictly monitored under EU REACH and FDA guidelines—requiring high-purity, low-residue variants.
Top 10 Manufacturers of CAS No. 872-53-7
1. BASF
Location: Ludwigshafen, Germany
Overview: One of the world’s largest NMP producers, supplying high-purity grades for pharmaceutical synthesis.
Specialty: Pharma-grade solvents with full REACH, USP, and ICH documentation.
2. Ashland Global
Location: Wilmington, Delaware, USA
Overview: Key supplier of specialty pharmaceutical excipients and intermediates, including NMP.
Specialty: Controlled-grade NMP suitable for transdermal and parenteral applications.
Overview: Trusted supplier of high-purity N-Methyl-2-pyrrolidone for pharmaceutical and fine chemical applications.
Specialty: Export-oriented manufacturing with a focus on regulatory-compliant solvent quality.
4. Jubilant Ingrevia
Location: Uttar Pradesh, India
Overview: Manufacturer of NMP and pyrrolidone derivatives for global life science markets.
Specialty: Vertical integration and large-volume supply to regulated markets.
5. LyondellBasell Industries
Location: Rotterdam, Netherlands
Overview: Global petrochemical firm producing industrial and pharma-grade NMP.
Specialty: Extensive distribution network and full quality traceability.
6. WeylChem International
Location: Frankfurt, Germany
Overview: Offers custom synthesis services and specialty solvents, including NMP variants for regulated pharma use.
Specialty: Advanced purification processes and documentation support.
7. Aarti Pharmalabs
Location: Maharashtra, India
Overview: Supplier of pyrrolidone-based intermediates and solvents for APIs and excipients.
Specialty: High-quality supply for formulation and synthesis-grade NMP.
8. Farmhispania Group
Location: Barcelona, Spain
Overview: European CDMO using NMP in high-complexity API manufacturing.
Specialty: Known for compliance with EMA and USFDA process requirements.
9. Taminco (a subsidiary of Eastman Chemical Company)
Location: Ghent, Belgium
Overview: Supplier of amine-based solvents and pyrrolidone derivatives.
Specialty: Technical expertise in pharma-relevant solvent design and performance.
10. Delmar Chemicals
Location: Montreal, Canada
Overview: North American CDMO using NMP in specialized organic synthesis workflows.
Specialty: High-purity solvent handling and cGMP-certified operations.
Trends in the Pharmaceutical Intermediates Market
Rising Demand for High-Purity Solvents
CAS 872-53-7 is gaining attention in highly regulated drug applications, especially injectables and transdermal systems.
Regulatory Pressure for Safer Use
EU REACH and global safety authorities are tightening permissible exposure levels for NMP, pushing producers to improve purification and handling.
Shift to Greener Alternatives
While NMP is still dominant, research into less toxic alternatives is gaining pace, particularly for sensitive formulations.
Integration in Complex Formulations
NMP’s penetration-enhancing and solubilizing characteristics are increasingly utilized in drug delivery systems.
Global Supply Chain Diversification
Pharma companies seek reliable, compliant suppliers from diverse geographies for security and cost efficiency.
Conclusion
CAS No. 872-53-7, or N-Methyl-2-pyrrolidone (NMP), is a multipurpose pharmaceutical intermediate and solvent critical to modern drug synthesis and delivery. As demand for high-purity, pharmaceutically accepted solvents grows, reliable suppliers like Eastfine, BASF, Ashland, and Jubilant are vital to the continued development and scaling of complex drug formulations.
Whether used in synthesis or as a formulation component, the quality, traceability, and compliance of NMP will remain essential in regulated pharmaceutical markets worldwide.
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