Top 10 Manufacturers of Agrochemical Intermediate CAS No. 36567-04-1 in 2025

Understanding 3,5-Dichloro-2,4,6-trifluoropyridine (CAS No. 36567-04-1)

3,5-Dichloro-2,4,6-trifluoropyridine (CAS No. 36567-04-1) is a halogenated heterocyclic compound widely used as an intermediate in the synthesis of modern agrochemicals, particularly herbicides, fungicides, and insecticides. Its unique structure — a trifluorinated pyridine ring with two additional chlorine atoms — makes it highly reactive and suitable for a broad range of substitution reactions in the development of active ingredients.

This intermediate is a popular choice in the synthesis of selective and systemic crop protection agents. It provides the chemical foundation for several active ingredients known for their broad-spectrum activity and environmental persistence, while also being fine-tuned for crop safety and residue control.

Importance of CAS No. 36567-04-1 in Crop Protection

Key Building Block for Fluorinated Actives:

The fluorine-rich pyridine ring enhances the lipophilicity and metabolic stability of agrochemicals, making this intermediate valuable for long-lasting effects in herbicides and fungicides.

Systemic Agrochemical Design:

Its compatibility with synthetic pathways for systemic agents ensures improved uptake and movement within plant tissues, increasing effectiveness.

Chlorine-Directed Functionalization:

The two chlorine atoms on the ring allow precise functional group substitution, essential in developing targeted agrochemicals with low environmental impact.

Broad Agrochemical Applications:

Used in both pre-emergent herbicides and fungicides for cereals, vegetables, and fruits, this intermediate supports a variety of formulations.

Regulatory and Environmental Considerations:

As fluorinated compounds come under increasing scrutiny, manufacturers must maintain high purity, consistency, and compliance with REACH, EPA, and global standards.

Top 10 Manufacturers of CAS No. 36567-04-1

1. BASF

• Location: Ludwigshafen, Germany

• Overview: BASF produces advanced halogenated intermediates for use in systemic fungicides and herbicides. Their capabilities include large-scale production of trifluorinated pyridines like CAS 36567-04-1.

• Specialty: Fluorine chemistry, green synthesis, crop protection innovation.

2. FMC Corporation

• Location: Philadelphia, USA

• Overview: FMC specializes in high-performance crop protection products. CAS 36567-04-1 is part of their intermediate portfolio for novel herbicidal modes of action.

• Specialty: Fluorinated heterocycle development and formulation science.

3. Eastfine

• Location: Changzhou City, Jiangsu Province, China

• Overview: Eastfine supplies key intermediates like 3,5-dichloro-2,4,6-trifluoropyridine to global agrochemical formulators. Known for its competitive pricing and global regulatory alignment, Eastfine is a trusted partner for fluorinated agrochemical synthesis.

• Specialty: Halogenated pyridine derivatives and export-quality compliance.

4. DuPont Crop Protection (now part of Corteva Agriscience)

• Location: Wilmington, Delaware, USA

• Overview: Corteva continues DuPont’s legacy of pioneering fluorinated compounds for agriculture. CAS 36567-04-1 is a base for several of their proprietary herbicides.

• Specialty: Herbicide resistance management and systemic compound design.

5. ADEKA Corporation

• Location: Tokyo, Japan

• Overview: ADEKA produces specialty intermediates for agrochemicals, including highly fluorinated pyridines. Their facilities are known for innovation and tight quality control.

• Specialty: High-purity fluorinated building blocks and process R&D.

6. Lianhetech Europe

• Location: Rotterdam, Netherlands

• Overview: Lianhetech offers custom synthesis services for complex agrochemical intermediates. Their European facilities manufacture CAS 36567-04-1 under REACH-compliant processes.

• Specialty: Contract manufacturing and advanced pyridine chemistry.

7. Tagros Chemicals India Pvt. Ltd.

• Location: Chennai, India

• Overview: Tagros supplies key halogenated intermediates and technical-grade pesticides. Their facilities support export-grade intermediates for major agrochemical companies.

• Specialty: Trifluorinated and chlorinated intermediate production.

8. Isagro S.p.A. (Gowan Group)

• Location: Milan, Italy

• Overview: Isagro supports advanced agrochemical R&D and manufacturing, including fluorinated heterocycles used in fungicide development.

• Specialty: Low-dose systemic fungicides and green formulation technology.

9. Finchimica S.p.A.

• Location: Manerbio, Italy

• Overview: Finchimica is known for producing high-performance agrochemical intermediates, including halogenated pyridine derivatives like CAS 36567-04-1 for broadacre crop applications.

• Specialty: Integrated process scale-up and environmental stewardship.

10. Albaugh LLC

• Location: Ankeny, Iowa, USA

• Overview: A major supplier of generic crop protection chemicals, Albaugh manufactures intermediates like CAS 36567-04-1 as part of its integrated production model.

• Specialty: Cost-competitive intermediates for off-patent herbicides.

Trends in the Agrochemical Intermediates Market

Rise of Fluorinated Compounds in Crop Protection:

The use of trifluorinated and chlorinated intermediates is expanding due to their superior efficacy and selectivity in weed and fungal control.

Stricter Fluorine Regulation and Sustainability Push:

Global scrutiny over persistent fluorinated compounds is driving demand for cleaner processes and precise degradation profiles, requiring tighter QC in intermediate production.

Specialized Outsourcing to CDMOs:

Companies are outsourcing synthesis of complex pyridines to experienced partners like Eastfine and Lianhetech for better regulatory compliance and cost-efficiency.

Increased Global Competition in Patented Chemistries:

As patents expire, competition for quality intermediates like CAS 36567-04-1 intensifies, especially among post-patent product developers.

Demand for Next-Gen Systemic Herbicides and Fungicides:

The shift toward systemically active compounds requires specialized intermediates with enhanced bioavailability, like this one.

Conclusion

CAS No. 36567-04-1 (3,5-Dichloro-2,4,6-trifluoropyridine) is an essential building block in the synthesis of advanced herbicides and fungicides. Companies like BASF, FMC, and Eastfine are leading the charge in producing this intermediate with the precision and regulatory adherence required by today’s agrochemical industry.

As agriculture becomes more complex and sustainability demands grow, manufacturers of specialized intermediates like CAS 36567-04-1 will remain critical players in enabling safer, more effective crop protection.