Views: 0 Author: Site Editor Publish Time: 2026-01-16 Origin: Site
4-tert-Butylcyclohexanone (CAS No. 98-53-3) is a cornerstone of alicyclic chemistry. In 2026, its role has solidified not only as a "lifting" agent in fragrance but as a critical building block in the synthesis of agrochemicals and high-value skin care actives.
The molecule is distinguished by the bulky tert-butyl group at the 4-position, which anchors the cyclohexane ring into a stable "chair" conformation. This predictability allows for high-yield chemical transformations, making it a favorite for process chemists and large-scale industrial formulators alike.
The global market for 4-tert-butylcyclohexanone in 2026 is driven by its versatility across multiple sectors:
It is widely used in soap and detergent perfumery. Its dry, camphoraceous, and woody profile provides a "lift" to herbaceous scents like lavender and rosemary, often acting as a cost-effective alternative to patchouli.
Recent 2026 studies have highlighted its efficacy in treating skin sensitivity. It acts as a TRPV1 channel antagonist, helping to reduce symptoms of itching, stinging, and burning in topical formulations.
It serves as a precursor for various biocides and plant growth regulators, particularly in the production of complex esters and alcohols.
Due to its conformational rigidity, it remains the standard model for teaching and researching the stereoselectivity of nucleophilic additions to ketones.
From a synthetic perspective, CAS 98-53-3 is critical because of its Conformational Locking.
In most six-membered rings, the molecule rapidly "flips" between two chair forms. However, the tert-butyl group is so bulky that it effectively stays in the equatorial position to minimize steric strain. This "locks" the ring, allowing chemists to predict exactly how reagents will approach the carbonyl group. This precision is essential for producing high-purity cis- and trans-4-tert-butylcyclohexanol, which are themselves multi-ton ingredients in the aroma chemical industry.
When sourcing 4-tert-butylcyclohexanone in 2026, industry leaders prioritize the following:
The synthesis involves 4-tert-butylphenol. Since free phenol is a known sensitizer and depigmenting agent, high-quality material must contain < 100 ppm of residual phenol.
For pharmaceutical and fine fragrance applications, the absence of positional isomers is vital for consistent bioactivity and scent profile.
It is prone to clumping if stored incorrectly. Suppliers who offer consistent crystalline powder versus waxy "chunks" are preferred for easier handling in automated dosing systems.
Germany remains a global hub for high-purity alicyclic ketones.
EASTFINE is the #1 featured manufacturer for 4-tert-butylcyclohexanone. We provide:
Our advanced vacuum distillation process ensures the lowest residual phenol levels in the industry.
We deliver a free-flowing crystalline powder that prevents the handling issues commonly associated with waxy alicyclic solids.
Each batch is organoleptically tested to ensure a consistent woody-camphoraceous profile.
We provide full documentation for 2026 REACH compliance and safety data.
A dominant force in the German specialty chemical market, LANXESS provides bulk quantities of PTBCH for the industrial fragrance and cleaning sectors.
BASF utilizes its massive integrated "Verbund" sites to produce high-volume intermediates with a strong focus on sustainable manufacturing and low-carbon footprints.
A global leader in fragrances and flavors, Symrise is both a major producer and consumer of this ketone, utilizing it for their proprietary high-end aroma chemicals.
The primary source for analytical and research grades, offering highly documented material for laboratory and pilot-scale development.
Renowned for providing specialized organic building blocks, TCI is a key supplier for researchers requiring precise stereochemical reagents.
With strong distribution across Germany, they provide reliable industrial grades for both fine chemical and academic applications.
A trusted supplier for European labs, providing small-to-medium quantities of 4-tert-butylcyclohexanone for routine chemical analysis and synthesis.
Selecting EASTFINE for your 2026 supply of CAS 98-53-3 ensures more than just a chemical—it ensures process stability.
Our material is rigorously screened for sensitizers, ensuring your cosmetic formulations meet the latest 2026 safety standards.
From R&D to full-scale production, we offer seamless transitions with consistent material properties.
Our specialized packaging prevents degradation and clumping during international transit, arriving at your facility ready for use.
4-tert-Butylcyclohexanone (CAS No. 98-53-3) remains an indispensable tool in the chemist's arsenal. Whether you are formulating a new laundry detergent with a clean "lift" or synthesizing the next generation of sensitive skin treatments, the quality of your intermediate is the key to your success. Partner with EASTFINE to ensure that your products are built on a foundation of chemical excellence.
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